Macroautophagy (autophagy) is a process wherein bulk cytosolic proteins and damaged
organelles are sequestered and degraded via the lysosome. Alterations in autophagy …

Autophagy, mediated by a number of autophagy‐related (ATG) proteins, plays an important
role in the bulk degradation of cellular constituents. Beclin‐1 (also known as Atg6 in yeast) is …

Autophagy is crucial for maintaining cell homeostasis. However, the precise mechanism
underlying autophagy initiation remains to be defined. Here, we demonstrate that glutamine …

The activation of the NLRP3 inflammasome signaling pathway plays an important role in the
neuroinflammation in Alzheimer's disease (AD). In this study, we investigated the effects of …

Autophagy is an essential cellular process that removes harmful protein species, and
autophagy upregulation may be able to protect against neurodegeneration and various …

Appropriate autophagy has protective effects on ischemic nerve tissue, while excessive
autophagy may cause cell death. The inflammatory response plays an important role in the …

Autophagy is a conserved intracellular degradation pathway essential for protein
homeostasis, survival and development. Defects in autophagic pathways have been …

Background The contributions of brain intercellular communication mechanisms, specifically
extracellular vesicles (EV), to the progression of Alzheimer's disease (AD) remain poorly …

The innate immune system and inflammatory response in the brain have critical impacts on
the pathogenesis of many neurodegenerative diseases including Alzheimer's disease (AD) …

Historically neurodegenerative diseases, Alzheimer's disease (AD) in particular, have been
viewed to be primarily caused and driven by neuronal mechanisms. Very recently, due to …