Microglial NLRP3 inflammasome activation is emerging as a key contributor to
neuroinflammation during neurodegeneration. Pathogenic protein aggregates such as β …

The innate immune system and inflammatory response in the brain have critical impacts on
the pathogenesis of many neurodegenerative diseases including Alzheimer's disease (AD) …

Misfolded proteins are pathological findings in some chronic neurodegenerative disorders
including Alzheimer's, Parkinson's, and Huntington's diseases. Aging is a major risk factor …

Autophagy is an intracellular degradation process to clear up aggregated proteins or aged
and damaged organelles. The Beclin1-Vps34-Atg14L complex is essential for …

An update on pathogenesis of Alzheimer's disease, the present document describes the
crosstalk between autophagy and inflammation in Alzheimer's disease progression by …

Activation of the inflammasome is implicated in the pathogenesis of an increasing number of
inflammatory diseases, including Alzheimer's disease (AD). Research reporting …

Autophagy and apoptosis are two important and interconnected stress-response
mechanisms. However, the molecular interplay between these two pathways is not fully …

Alzheimer's disease (AD) is the most common cause of progressive dementia in the elderly.
It is characterized by a progressive and irreversible loss of cognitive abilities and formation …

Autophagy plays an important role in cellular quality control and is responsible for removing
protein aggregates and dysfunctional organelles. Bnip3 is an atypical BH3-only protein that …

Autophagy is a highly conserved process by which long-lived macromolecules, protein
aggregates and dysfunctional/damaged organelles are delivered to lysosomes for …