In the CNS, the transcription factor NF-κB is a key regulator of inflammation and secondary
injury processes. Following trauma or disease, the expression of NF-κB-dependent genes is …

Astrocytes respond to insult with a process of cellular activation known as reactive
astrogliosis. One of the key signals regulating this phenomenon is the transcription factor …

Background Optic neuritis is an acute, demyelinating neuropathy of the optic nerve often
representing the first appreciable symptom of multiple sclerosis. Wallerian degeneration of …

In the central nervous system (CNS), the transcription factor nuclear factor (NF)-κ B is a key
regulator of inflammation and secondary injury processes. After trauma or disease, the …

Activation of transcription factor NF-κB in the central nervous system (CNS) has been linked
to autoimmune demyelinating disease; however, it remains unclear whether its function is …

Experimental autoimmune encephalomyelitis (EAE) is an inflammatory disease of the CNS,
which has long been used as an animal model for human multiple sclerosis. Development of …

NF-κB is an inducible transcription factor involved in the induction of multiple genes during
inflammatory processes. So far the information pertaining to the role of NF-κB in autoimmune …

Neurodegeneration is the irremediable pathological event occurring during chronic
inflammatory diseases of the CNS. Here we show that, in experimental autoimmune …

Tissue response to injury includes expression of genes encoding cytokines and
chemokines. These regulate entry of immune cells to the injured tissue. The synthesis of …

The transcription factor nuclear factor κB (NF-κB) plays major roles in inflammatory diseases
through regulation of inflammation and cell viability. Multiple sclerosis (MS) is a chronic …