The synergistic effect of triterpenoids and flavonoids—New approaches for treating bacterial infections?

N Wrońska, M Szlaur, K Zawadzka, K Lisowska - Molecules, 2022 - mdpi.com
Currently, the pharmaceutical industry is well-developed, and a large number of
chemotherapeutics are being produced. These include antibacterial substances, which can …

Synergistic antimicrobial activity between pentacyclic triterpenoids and antibiotics against Staphylococcus aureus strains

PY Chung, P Navaratnam, LY Chung - Annals of clinical microbiology and …, 2011 - Springer
Background There has been considerable effort to discover plant-derived antibacterials
against methicillin-resistant strains of Staphylococcus aureus (MRSA) which have …

Antibacterial activity and proposed action mechanism of a new class of synthetic tricyclic flavonoids

C Babii, LG Bahrin, AN Neagu, I Gostin… - Journal of Applied …, 2016 - academic.oup.com
Aims This study reports on the inhibitory and bactericidal properties of a new synthetized
flavonoid. Methods and Results Tricyclic flavonoid 1 has been synthesized through a two …

In vitro effectiveness of triterpenoids and their synergistic effect with antibiotics against Staphylococcus aureus strains

M Hamza, M Nadir, N Mehmood… - Indian Journal of …, 2016 - journals.lww.com
Objectives: The aim of this study is to evaluate the effect of four triterpenoids such as
oleanolic acid, ursolic acid, cycloastragenol, and beta-boswellic acid alone and in …

Pentacyclic triterpene derivatives possessing polyhydroxyl ring A inhibit Gram-positive bacteria growth by regulating metabolism and virulence genes expression

L Huang, H Luo, Q Li, D Wang, J Zhang, X Hao… - European Journal of …, 2015 - Elsevier
The hydroxyl group in ring A of pentacyclic triterpene is essential for antibacterial activity.
Pentacyclic triterpenes bearing three hydroxyl groups in ring A were mainly found in plants …

Antimicrobial activity of a new class of phosphorylated and modified flavonoids

FJ Osonga, A Akgul, RM Miller, GB Eshun, I Yazgan… - ACS …, 2019 - ACS Publications
The surge of resistant food pathogens is a major threat worldwide. Previous research
conducted on phytochemicals has shown their antibacterial activity against pathogenic …

Plant phenolics and terpenoids as adjuvants of antibacterial and antifungal drugs

SA Zacchino, E Butassi, M Di Liberto, M Raimondi… - Phytomedicine, 2017 - Elsevier
Background The intensive use of antibacterial and antifungal drugs has dramatically
increased the microbial resistance and has led to a higher number of difficult-to-eradicate …

Antibacterial effects of flavonoids and their structure-activity relationship study: A comparative interpretation

NF Shamsudin, QU Ahmed, S Mahmood, SA Ali Shah… - Molecules, 2022 - mdpi.com
According to the latest report released by the World Health Organization, bacterial
resistance to well-known and widely available antibacterial drugs has become a significant …

Anti-planktonic and anti-biofilm properties of pentacyclic triterpenes—asiatic acid and ursolic acid as promising antibacterial future pharmaceuticals

Z Sycz, D Tichaczek-Goska, D Wojnicz - Biomolecules, 2022 - mdpi.com
Due to the ever-increasing number of multidrug-resistant bacteria, research concerning
plant-derived compounds with antimicrobial mechanisms of action has been conducted …

Antimicrobial capacity of plant polyphenols against gram-positive bacteria: A comprehensive review

FJ Álvarez-Martínez, E Barrajón-Catalán… - Current medicinal …, 2020 - ingentaconnect.com
Background: Multi-drug-resistant bacteria such as Methicillin-Resistant Staphylococcus
aureus (MRSA) disseminate rapidly amongst patients in healthcare facilities and suppose …