In recent years, tremendous advances have been made in the use of gene editing to
precisely engineer the genome. This technology relies on the activity of a wide range of …

Genome editing technologies have advanced significantly over the past few years, providing
a fast and effective tool to precisely manipulate the genome at specific locations. The three …

In the field of hematology, gene therapies based on integrating vectors have reached
outstanding results for a number of human diseases. With the advent of novel programmable …

The possibility of editing complex genomes in a targeted fashion has revolutionized basic
research as well as biomedical and biotechnological applications in the last 5 years. The …

Advances in genome engineering in the last decade, particularly in the development of
programmable nucleases, have made it possible to edit the genomes of most cell types …

Recent advances in genome editing tools, especially novel developments in the clustered
regularly interspaced short palindromic repeats associated to Cas9 nucleases …

The rapid advancement of genome-editing techniques holds much promise for the field of
human gene therapy. From bacteria to model organisms and human cells, genome editing …

Today gene therapy is a real therapeutic option to address inherited hematological diseases
that could be beneficial for thousands of patients worldwide. Currently, gene therapy is used …

Genome editing of hematopoietic stem and progenitor cells is being developed for the
treatment of several inherited disorders of the hematopoietic system. The adaptation of …

The use of precise, rationally designed gene-editing nucleases allows for targeted genome
and transcriptome modification, and at present, four major classes of nucleases are being …