EGFR mutation mediates resistance to EGFR tyrosine kinase inhibitors in NSCLC: From molecular mechanisms to clinical research
RF Dong, ML Zhu, MM Liu, YT Xu, LL Yuan… - Pharmacological …, 2021 - Elsevier
With the development of precision medicine, molecular targeted therapy has been widely
used in the field of cancer, especially in non-small-cell lung cancer (NSCLC). Epidermal …
used in the field of cancer, especially in non-small-cell lung cancer (NSCLC). Epidermal …
[HTML][HTML] EGFR-TKI resistance in NSCLC patients: mechanisms and strategies
Y Lin, X Wang, H Jin - American journal of cancer research, 2014 - ncbi.nlm.nih.gov
The epidermal growth factor receptor (EGFR) is a kind of receptor tyrosine kinase (RTK) that
plays a critical role in the initiation and development of malignant tumors via modulating …
plays a critical role in the initiation and development of malignant tumors via modulating …
EGFR as a pharmacological target in EGFR-mutant non-small-cell lung cancer: where do we stand now?
YL Wu - Trends in Pharmacological Sciences, 2016 - cell.com
Targeting the epidermal growth factor receptor (EGFR) using tyrosine kinase inhibitors
(TKIs) is highly effective in terms of tumor response rate, survival, and quality of life …
(TKIs) is highly effective in terms of tumor response rate, survival, and quality of life …
Mechanisms of resistance to epidermal growth factor receptor inhibitors and novel therapeutic strategies to overcome resistance in NSCLC patients
L Lin, TG Bivona - Chemotherapy research and practice, 2012 - Wiley Online Library
The epidermal growth factor receptor (EGFR) is a well‐characterized oncogene that is
frequently activated by somatic kinase domain mutations in non‐small cell lung cancer …
frequently activated by somatic kinase domain mutations in non‐small cell lung cancer …
[HTML][HTML] Mechanisms of resistance to EGFR tyrosine kinase inhibitors
L Huang, L Fu - Acta Pharmaceutica Sinica B, 2015 - Elsevier
Since the discovery that non-small cell lung cancer (NSCLC) is driven by epidermal growth
factor receptor (EGFR) mutations, the EGFR tyrosine kinase inhibitors (EGFR-TKIs, eg …
factor receptor (EGFR) mutations, the EGFR tyrosine kinase inhibitors (EGFR-TKIs, eg …
[HTML][HTML] The resistance mechanisms and treatment strategies for EGFR-mutant advanced non-small-cell lung cancer
WZ Zhong, Q Zhou, YL Wu - Oncotarget, 2017 - ncbi.nlm.nih.gov
Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKI) have been
established as the standard therapy for EGFR-sensitizing mutant advanced non-small-cell …
established as the standard therapy for EGFR-sensitizing mutant advanced non-small-cell …
Mechanism of resistance to epidermal growth factor receptor-tyrosine kinase inhibitors and a potential treatment strategy
T Nagano, M Tachihara, Y Nishimura - Cells, 2018 - mdpi.com
Treatment with epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs)
improves the overall survival of patients with EGFR-mutated non-small-cell lung cancer …
improves the overall survival of patients with EGFR-mutated non-small-cell lung cancer …
The resistance to EGFR-TKIs in non-small cell lung cancer: from molecular mechanisms to clinical application of new therapeutic strategies
C Laface, FM Maselli, AN Santoro, ML Iaia, F Ambrogio… - Pharmaceutics, 2023 - mdpi.com
Almost 17% of Western patients affected by non-small cell lung cancer (NSCLC) have an
activating epidermal growth factor receptor (EGFR) gene mutation. Del19 and L858R are the …
activating epidermal growth factor receptor (EGFR) gene mutation. Del19 and L858R are the …
Molecular mechanisms of resistance in epidermal growth factor receptor-mutant lung adenocarcinomas
AB Cortot, PA Jänne - European Respiratory Review, 2014 - Eur Respiratory Soc
The discovery of epidermal growth factor receptor (EGFR) mutations in nonsmall cell lung
cancer (NSCLC) has allowed the identification of a subset of patients whose tumours are …
cancer (NSCLC) has allowed the identification of a subset of patients whose tumours are …
Intrinsic resistance to EGFR tyrosine kinase inhibitors in advanced non-small-cell lung cancer with activating EGFR mutations
J Wang, B Wang, H Chu, Y Yao - OncoTargets and therapy, 2016 - Taylor & Francis
Identifying activating EGFR mutations is a useful predictive strategy that helps select a
population of advanced non-small-cell lung cancer (NSCLC) patients for treatment with …
population of advanced non-small-cell lung cancer (NSCLC) patients for treatment with …
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