Augmented glycolysis due to metabolic reprogramming in lung myofibroblasts is critical to
their profibrotic phenotype. The primary glycolysis byproduct, lactate, is also secreted into …

Metabolic reprogramming has been intrinsically linked to macrophage activation. Alveolar
macrophages are known to play an important role in the pathogenesis of pulmonary fibrosis …

Rationale: Idiopathic pulmonary fibrosis (IPF) is a complex disease for which the
pathogenesis is poorly understood. In this study, we identified lactic acid as a metabolite that …

Myofibroblasts, the major effector cells in pathologic fibrosis, derive from the differentiation of
fibroblasts driven by mediators such as transforming growth factor-β1 (TGF-β1) and …

Pulmonary fibrosis is a progressive and intractable lung disease with fibrotic features that
affects alveoli elasticity, which leading to higher rates of hospitalization and mortality …

Rationale: Dysregulation of cellular metabolism has been shown to participate in several
pathologic processes. However, the role of metabolic reprogramming is not well appreciated …

Little is known about the relative importance of monocyte and tissue-resident macrophages
in the development of lung fibrosis. We show that specific genetic deletion of monocyte …

Idiopathic pulmonary fibrosis is a pathological result of dysfunctional repair response to
tissue injury, leading to chronically impaired gas exchange and death. Macrophages are …

Fibrosis is the final pathological outcome and major cause of morbidity and mortality in many
common and chronic inflammatory, immune-mediated, and metabolic diseases. Despite the …

Stress that impairs endoplasmic reticulum (ER) function leads to an accumulation of
unfolded or misfolded proteins in the ER (ER stress) and triggers the unfolded protein …