Chronic binge ethanol-mediated acidemia reduces availability of glutamine and related amino acids in maternal plasma of pregnant sheep

J Ramadoss, G Wu, TA Cudd - Alcohol, 2008 - Elsevier
Heavy drinking during pregnancy can result in fetal alcohol syndrome (FAS), of which, fetal
and postnatal growth retardation and central nervous system deficits are cardinal features …

Acute alcohol exposure, acidemia or glutamine administration impacts amino acid homeostasis in ovine maternal and fetal plasma

SE Washburn, OB Sawant, ER Lunde, G Wu, TA Cudd - Amino acids, 2013 - Springer
Fetal alcohol syndrome (FAS) is a significant problem in human reproductive medicine.
Maternal alcohol administration alters maternal amino acid homeostasis and results in …

Effects of l-glutamine supplementation on maternal and fetal hemodynamics in gestating ewes exposed to alcohol

OB Sawant, J Ramadoss, GD Hankins, G Wu… - Amino Acids, 2014 - Springer
Not much is known about effects of gestational alcohol exposure on maternal and fetal
cardiovascular adaptations. This study determined whether maternal binge alcohol …

Third trimester binge ethanol exposure results in fetal hypercapnea and acidemia but not hypoxemia in pregnant sheep

TA Cudd, WJA Chen, SE Parnell… - Alcoholism: Clinical and …, 2001 - Wiley Online Library
Background: The mechanisms by which maternal ethanol abuse during pregnancy causes
neurodevelopmental injury in the fetus are not well understood. The purpose of this study …

Maternal l-glutamine supplementation prevents prenatal alcohol exposure-induced fetal growth restriction in an ovine model

OB Sawant, G Wu, SE Washburn - Amino Acids, 2015 - Springer
Prenatal alcohol exposure is known to cause fetal growth restriction and disturbances in
amino acid bioavailability. Alterations in these parameters can persist into adulthood and …

Ethanol elevates fetal serum glutamate levels in the rat

PI Karl, R Kwun, A Slonim… - Alcoholism: Clinical and …, 1995 - Wiley Online Library
Glutamate is an important excitatory neurotransmitter. However, a sustained elevation of
glutamate in the extracellular space may be toxic to neurons. Because the blood‐brain …

Chronic ethanol exposure inhibits insulin and IGF‐1 stimulated amino acid uptake in cultured human placental trophoblasts

PI Karl, SE Fisher - Alcoholism: clinical and experimental …, 1994 - Wiley Online Library
Maternal alcohol abuse during pregnancy can lead to abnormalities in fetal development,
sometimes manifested as the fetal alcohol syndrome (FAS). Although intrauterine growth …

Selective fetal malnutrition: Effect of acute and chronic ethanol exposure upon rat placental Na, K‐ATPase activity

SE Fisher, L Duffy, M Atkinson - Alcoholism: Clinical and …, 1986 - Wiley Online Library
Intrauterine growth retardation (IUGR) is characteristic of the fetal alcohol syndrome (FAS).
This IUGR is partly due to the toxic effect of ethanol upon placental function, including amino …

Dose‐dependent effects of acute in vivo ethanol exposure on extracellular glutamate concentration in the cerebral cortex of the near‐term fetal sheep

JD Reynolds, DH Penning, F Dexter… - Alcoholism: Clinical …, 1995 - Wiley Online Library
The cerebral cortex is a target site of ethanol teratogenesis. l‐Glutamate is a major excitatory
neurotransmitter that plays an important neurotrophic role in brain development. It has been …

Effect of acute, multiple-dose ethanol on maternal and fetal blood gases and acid–base balance in the near-term pregnant ewe

GN Smith, JF Brien, L Carmichael… - Canadian journal of …, 1989 - cdnsciencepub.com
The effect of ethanol on maternal and fetal blood gases and acid–base balance was
determined in six conscious instrumented near-term pregnant ewes for maternal intravenous …