Current perspectives on pharmacotherapy of Alzheimer's disease

K Chopra, S Misra, A Kuhad - Expert opinion on pharmacotherapy, 2011 - Taylor & Francis
Introduction: Alzheimer's disease (AD) is a daunting public health threat that has prompted
the scientific community's ongoing efforts to decipher the underlying disease mechanism …

Overcoming translational barriers impeding development of Alzheimer's disease modifying therapies

TE Golde - Journal of neurochemistry, 2016 - Wiley Online Library
It has now been~ 30 years since the Alzheimer's disease (AD) research entered what may
be termed the 'molecular era'that began with the identification of the amyloid β protein (Aβ) …

Alzheimer's disease: strategies for disease modification

M Citron - Nature reviews Drug discovery, 2010 - nature.com
Alzheimer's disease is the largest unmet medical need in neurology. Current drugs improve
symptoms, but do not have profound disease-modifying effects. However, in recent years …

Strategies, development, and pitfalls of therapeutic options for Alzheimer's disease

C Haas - Journal of Alzheimer's Disease, 2012 - content.iospress.com
Therapeutic options for Alzheimer's disease are currently limited to symptomatic treatment
that only provides modest and temporary maintenance of cognitive and memory functions …

Emerging therapeutics for Alzheimer's disease

K Chiang, EH Koo - Annual review of pharmacology and …, 2014 - annualreviews.org
Despite decades of intense research, therapeutics for Alzheimer's disease (AD) are still
limited to symptomatic treatments that possess only short-term efficacy. Recently, several …

Challenges in the treatment of Alzheimer's disease: recent progress and treatment strategies of pharmaceuticals targeting notable pathological factors

YC Kuo, R Rajesh - Expert review of neurotherapeutics, 2019 - Taylor & Francis
Introduction: Alzheimer's disease (AD), a commonly encountered neurodegenerative
disorder, causes cognitive decline and has a devastating effect on the quality of life. AD …

Current and emerging pharmacological targets for the treatment of Alzheimer's disease

A Morsy, PC Trippier - Journal of Alzheimer's Disease, 2019 - content.iospress.com
No cure or disease-modifying therapy for Alzheimer's disease (AD) has yet been realized.
However, a multitude of pharmacological targets have been identified for possible …

Therapeutic approaches for the treatment of Alzheimer's disease: an overview

LF Lau, MA Brodney - Alzheimer's Disease, 2008 - Springer
Alzheimer's disease (AD) is a neurodegenerative disease that robs the minds of our elderly
population. Approximately one in every eight adults over the age of 65 and nearly half of …

Discontinued disease-modifying therapies for Alzheimer's disease: status and future perspectives

BP Imbimbo, M Lozupone, M Watling… - Expert opinion on …, 2020 - Taylor & Francis
Introduction Alzheimer's disease (AD) is the main cause of dementia and represents a huge
burden for patients, carers, and healthcare systems. Extensive efforts for over 20 years have …

Current druggable targets for therapeutic control of Alzheimer's disease

GL Gupta, NP Samant - Contemporary Clinical Trials, 2021 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative brain disorder that has an increasingly
large burden on health and social care systems. The pathophysiology involves the …