Current druggable targets for therapeutic control of Alzheimer's disease
GL Gupta, NP Samant - Contemporary Clinical Trials, 2021 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative brain disorder that has an increasingly
large burden on health and social care systems. The pathophysiology involves the …
large burden on health and social care systems. The pathophysiology involves the …
Beyond amyloid: the future of therapeutics for Alzheimer's disease
RF Lane, DW Shineman, JW Steele, LBH Lee… - Advances in …, 2012 - Elsevier
Currently, the field is awaiting the results of several pivotal Phase III clinical Alzheimer's
disease (AD) trials that target amyloid-β (Aβ). In light of the recent biomarker studies that …
disease (AD) trials that target amyloid-β (Aβ). In light of the recent biomarker studies that …
Should drug discovery scientists still embrace the amyloid hypothesis for Alzheimer's disease or should they be looking elsewhere?
BP Imbimbo, S Ippati, M Watling - Expert Opinion on Drug …, 2020 - Taylor & Francis
ABSTRACT Introduction Alzheimer's Disease (AD) represents a large and growing
challenge to patients, carers and healthcare systems, yet extensive efforts to develop …
challenge to patients, carers and healthcare systems, yet extensive efforts to develop …
Advances in the therapy of Alzheimer's disease: targeting amyloid beta and tau and perspectives for the future
H Hampel, LS Schneider, E Giacobini… - Expert review of …, 2015 - Taylor & Francis
Worldwide multidisciplinary translational research has led to a growing knowledge of the
genetics and molecular pathogenesis of Alzheimer's disease (AD) indicating that …
genetics and molecular pathogenesis of Alzheimer's disease (AD) indicating that …
Emerging therapeutics for Alzheimer's disease
ERLC Vardy, I Hussain, NM Hooper - Expert Review of …, 2006 - Taylor & Francis
Alzheimer's disease (AD) is the most common form of dementia, with prevalence and the
accompanying socioeconomic impact set to increase over the coming decades. Currently …
accompanying socioeconomic impact set to increase over the coming decades. Currently …
Current therapeutic targets for Alzheimer's disease
Alzheimer's disease (AD) is one of the most common multifactorial diseases, including a
range of abnormal cellular/molecular processes occurring in different regions of the brain …
range of abnormal cellular/molecular processes occurring in different regions of the brain …
Therapeutic approaches to Alzheimer's disease
HW Klafki, M Staufenbiel, J Kornhuber, J Wiltfang - Brain, 2006 - academic.oup.com
Alzheimer's disease is an age-related progressive neurodegenerative disorder with an
enormous unmet medical need. It is the most common form of dementia affecting∼ 5% of …
enormous unmet medical need. It is the most common form of dementia affecting∼ 5% of …
Current advances in the treatment of Alzheimer's disease: focused on considerations targeting Aβ and tau
Y Hong-Qi, S Zhi-Kun, C Sheng-Di - Translational neurodegeneration, 2012 - Springer
Alzheimer's disease (AD) is a neurodegenerative disorder that impairs mainly the memory
and cognitive function in elderly. Extracellular beta amyloid deposition and intracellular tau …
and cognitive function in elderly. Extracellular beta amyloid deposition and intracellular tau …
Tau spread, Apolipoprotein E, inflammation, and more: rapidly evolving basic science in Alzheimer disease
B Gonzalez, EM Abud, AM Abud… - Neurologic …, 2017 - neurologic.theclinics.com
To date, Alzheimer disease (AD) drug candidates have produced negative results in human
trials, and progress in moving new targets out of the laboratory and into trials has been slow …
trials, and progress in moving new targets out of the laboratory and into trials has been slow …
Recent therapeutic strategies targeting beta amyloid and tauopathies in Alzheimer's disease
Y Madav, S Wairkar, B Prabhakar - Brain research bulletin, 2019 - Elsevier
Alzheimer's disease (AD) has been a global concern for years due to its severe implications
that affects the quality of life of the patients. The available line of therapy for treating …
that affects the quality of life of the patients. The available line of therapy for treating …