Emerging treatments for Alzheimer's disease for non-amyloid and non-tau targets

A Khan, A Corbett, C Ballard - Expert review of neurotherapeutics, 2017 - Taylor & Francis
Introduction: The number of people with dementia, including Alzheimer's disease, is growing
as a result of an ageing global population. Treatments available for AD only alleviate the …

Therapeutic opportunities in Alzheimer disease: one for all or all for one?

MW Marlatt, KM Webber, PI Moreira… - Current medicinal …, 2005 - ingentaconnect.com
In recent years, Alzheimer disease (AD) has received great attention as an incurable and
fatal disease that threatens the lives of aging individuals. Debates regarding areas of …

Alzheimer's disease (AD) therapeutics–1: Repeated clinical failures continue to question the amyloid hypothesis of AD and the current understanding of AD causality

K Mullane, M Williams - Biochemical Pharmacology, 2018 - Elsevier
Deposits of amyloid plaques and neurofibrillary tangles of aggregated tau in the brain
represent key hallmarks of the neurodegenerative disorder, Alzheimer's Disease (AD) and …

Drugs for targeted therapies of Alzheimer's disease

C Tam, JH Wong, TB Ng, SKW Tsui… - Current medicinal …, 2019 - ingentaconnect.com
Alzheimer's disease (AD) is one type of neurodegenerative diseases, which is prevalent in
the elderly. Beta-amyloid (Aβ) plaques and phosphorylated tau-induced neurofibrillary …

Alzheimer disease clinical trials targeting amyloid: lessons learned from success in mice and failure in humans

AB Reiss, N Montufar, J DeLeon, A Pinkhasov… - The …, 2021 - journals.lww.com
Background: The goal of slowing or halting the development of Alzheimer disease (AD) has
resulted in the huge allocation of resources by academic institutions and pharmaceutical …

Emerging targets in neurodegeneration: new opportunities for Alzheimer's disease treatment?

A Rampa, S Gobbi, F Belluti… - Current Topics in Medicinal …, 2013 - ingentaconnect.com
Alzheimer's disease (AD) is a progressive neurodegenerative disorder of the brain
associated with memory impairment, progressive cognitive decline and changes in …

Alzheimer's targeted treatments: focus on amyloid and inflammation

T Iwatsubo, MC Irizarry, JW Lewcock… - Journal of …, 2023 - Soc Neuroscience
Alzheimer's disease (AD) is the major cause of dementia that is now threatening the lives of
billions of elderly people on the globe, and recent progress in the elucidation of the …

Emerging amyloid and tau targeting treatments for Alzheimer's disease

A Khan, A Corbett, C Ballard - Expert review of neurotherapeutics, 2017 - Taylor & Francis
Introduction: With an ageing global population, the number of people with dementia, and its
main cause Alzheimer's disease (AD), is growing. current licensed treatments available for …

New approaches to treating Alzheimer's disease

H Zheng, M Fridkin, M Youdim - Perspectives in medicinal …, 2015 - journals.sagepub.com
To date, no truly efficacious drugs for Alzheimer's disease (AD) have been developed;
moreover, all new anti-AD drugs developed since 2003 have failed. To succeed where …

[PDF][PDF] Current therapeutic strategy in Alzheimer's disease

S Singh, AS Kushwah, R Singh… - Eur Rev Med …, 2012 - europeanreview.org
Alzheimer's disease (AD) is a chronic, progressive, neurodegenerative disorder that places
a substantial burden on patients, their families, and society. Alzheimer's disease (AD) is the …