[PDF][PDF] Current therapeutic strategy in Alzheimer's disease

S Singh, AS Kushwah, R Singh… - Eur Rev Med …, 2012 - europeanreview.org
Alzheimer's disease (AD) is a chronic, progressive, neurodegenerative disorder that places
a substantial burden on patients, their families, and society. Alzheimer's disease (AD) is the …

New approaches to treating Alzheimer's disease

H Zheng, M Fridkin, M Youdim - Perspectives in medicinal …, 2015 - journals.sagepub.com
To date, no truly efficacious drugs for Alzheimer's disease (AD) have been developed;
moreover, all new anti-AD drugs developed since 2003 have failed. To succeed where …

Therapeutics of Alzheimer's disease: Past, present and future

R Anand, KD Gill, AA Mahdi - Neuropharmacology, 2014 - Elsevier
Alzheimer's disease (AD) is the most common cause of dementia worldwide. The etiology is
multifactorial, and pathophysiology of the disease is complex. Data indicate an exponential …

Current thinking on the mechanistic basis of Alzheimer's and implications for drug development

C Ising, M Stanley, DM Holtzman - Clinical Pharmacology & …, 2015 - Wiley Online Library
Alzheimer disease (AD) is the most common cause of dementia and is characterized by the
aggregation and accumulation of two proteins in the brain, amyloid‐β (Aβ) and tau. Aβ and …

New and emerging treatments for Alzheimer's disease

A Corbett, J Smith, C Ballard - Expert Review of Neurotherapeutics, 2012 - Taylor & Francis
Alzheimer's disease (AD) and other dementias represent a significant and increasing clinical
challenge. This review highlights current treatment options for AD and the main focusses of …

What is the rationale for new treatment strategies in Alzheimer's disease?

MA Rogawski - CNS spectrums, 2004 - cambridge.org
Alzheimer's disease (AD) is characterized by the abnormal extracellular accumulation of
amyloid β-peptide (Aβ) into neuritic plaques and the intraneuronal aggregation of the …

Review of advanced drug trials focusing on the reduction of brain beta-amyloid to prevent and treat dementia

B Decourt, K Noorda, K Noorda, J Shi… - Journal of …, 2022 - Taylor & Francis
Alzheimer disease (AD) is the most common neurodegenerative disease and typically
affects patients older than age 65. Around this age, the number of neurons begins to …

Reducing Aβ load and tau phosphorylation: Emerging perspective for treating Alzheimer's disease

J Kalra, A Khan - European journal of pharmacology, 2015 - Elsevier
Alzheimer's disease (AD) is a complex, progressive neurological disorder affecting elderly
population of above 65 years of age, characterized by failure of memory, loss of acquired …

The development of pharmacological therapies for Alzheimer's disease

P Lin, J Sun, Q Cheng, Y Yang, D Cordato… - Neurology and Therapy, 2021 - Springer
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that currently has no
cure. The aged population is growing globally, creating an urgent need for more promising …

Advances in recent patent and clinical trial drug development for Alzheimer's disease

H Liu, L Wang, W Su, XQ Xie - Pharmaceutical patent analyst, 2014 - Taylor & Francis
Alzheimer's disease (AD) is a progressive neurodegenerative disease, involving a large
number of genes, proteins and their complex interactions. Currently, no effective therapeutic …