Pathogenicity of human anti-PLA2R1 antibodies in minipigs: a pilot study
L Reinhard, T Wiech, A Reitmeier… - Journal of the …, 2023 - journals.lww.com
Background Primary membranous nephropathy (MN) is an autoimmune kidney disease in
which immune complexes are deposited beneath the epithelium in the glomeruli. The …
which immune complexes are deposited beneath the epithelium in the glomeruli. The …
Introduction of a novel chimeric active immunization mouse model of PLA2R1-associated membranous nephropathy
NM Tomas, A Schnarre, S Dehde, R Lucas… - Kidney International, 2023 - Elsevier
The phospholipase A2 receptor 1 (PLA2R1) is the major target antigen in patients with
membranous nephropathy (MN), an antibody-mediated autoimmune glomerular disease …
membranous nephropathy (MN), an antibody-mediated autoimmune glomerular disease …
Anti‐PLA2R1 antibodies containing sera induce In vitro cytotoxicity mediated by complement activation
M Lateb, H Ouahmi, C Payré, V Brglez… - Journal of …, 2019 - Wiley Online Library
The phospholipase A2 receptor (PLA2R1) is the major autoantigen in idiopathic
membranous nephropathy (MN). However, the pathogenic role of anti‐PLA2R1 …
membranous nephropathy (MN). However, the pathogenic role of anti‐PLA2R1 …
Evaluation of anti-PLA2R1 as measured by a novel ELISA in patients with idiopathic membranous nephropathy: a cohort study
SA Timmermans, JGMC Damoiseaux… - American journal of …, 2014 - academic.oup.com
Objectives: Autoantibodies against the M-type phospholipase A2 receptor 1 (anti-PLA2R1)
have been demonstrated to be very specific for idiopathic membranous nephropathy (MN) …
have been demonstrated to be very specific for idiopathic membranous nephropathy (MN) …
Membranous nephropathy: from models to man
As recently as 2002, most cases of primary membranous nephropathy (MN), a relatively
common cause of nephrotic syndrome in adults, were considered idiopathic. We now …
common cause of nephrotic syndrome in adults, were considered idiopathic. We now …
[HTML][HTML] Autoantibodies specific for the phospholipase A2 receptor in recurrent and de novo membranous nephropathy
H Debiec, L Martin, C Jouanneau, G Dautin… - American Journal of …, 2011 - Elsevier
Recent findings in idiopathic membranous nephropathy (MN) suggest that in most patients,
the disease is because of anti-phospholipase A 2 receptor (PLA 2 R1) autoantibodies. Our …
the disease is because of anti-phospholipase A 2 receptor (PLA 2 R1) autoantibodies. Our …
Toward a bona fide animal model of PLA2R1-associated membranous nephropathy: one step forward
The major form of membranous nephropathy is characterized by autoantibodies to
phospholipase A2 receptor 1 (PLA2R1). The study by Tomas et al. describes the first animal …
phospholipase A2 receptor 1 (PLA2R1). The study by Tomas et al. describes the first animal …
[PDF][PDF] Anti-PLA2R-associated membranous nephropathy: a review with emphasis on diagnostic testing methods
C VanBeek, M Haas - Clin Nephrol, 2015 - academia.edu
The majority of cases of primary membranous nephropathy (MN) are associated with auto-
antibodies against the podocyte antigen M-type phospholipase A2 receptor (PLA2R). This …
antibodies against the podocyte antigen M-type phospholipase A2 receptor (PLA2R). This …
M-Type Phospholipase A2 Receptor as Target Antigen in Idiopathic Membranous Nephropathy
LH Beck Jr, RGB Bonegio, G Lambeau… - … England Journal of …, 2009 - Mass Medical Soc
Background Idiopathic membranous nephropathy, a common form of the nephrotic
syndrome, is an antibody-mediated autoimmune glomerular disease. Serologic diagnosis …
syndrome, is an antibody-mediated autoimmune glomerular disease. Serologic diagnosis …
The characters of antibodies against PLA2R in healthy individuals and in the patient with PLA2R associated membranous nephropathy
Y Cheng, M Wang, J Wang, Z Cui, M Zhao - European journal of medical …, 2023 - Springer
Background Most primary membranous nephropathy (MN) is mediated by anti-
phospholipase A2 receptor (PLA2R) antibodies. Recently, these antibodies have been …
phospholipase A2 receptor (PLA2R) antibodies. Recently, these antibodies have been …