The genetics of isolated orofacial clefts: from genotypes to subphenotypes
A Jugessur, PG Farlie, N Kilpatrick - Oral diseases, 2009 - Wiley Online Library
Orofacial clefts are the most common craniofacial birth defects and one of the most common
congenital malformations in humans. They require complex multidisciplinary treatment and …
congenital malformations in humans. They require complex multidisciplinary treatment and …
Orofacial clefting: recent insights into a complex trait
A Jugessur, JC Murray - Current opinion in genetics & development, 2005 - Elsevier
Orofacial clefts are common birth defects of multifactorial etiology. Several novel approaches
have recently been applied to investigate the causes of clefts. These include examining …
have recently been applied to investigate the causes of clefts. These include examining …
The many faces and factors of orofacial clefts
BC Schutte, JC Murray - Human molecular genetics, 1999 - academic.oup.com
Orofacial clefts are congenital structural anomalies of the lip and/or palate that affect∼
1/1000 live births. Their frequent occurrence as well as their extensive psychological …
1/1000 live births. Their frequent occurrence as well as their extensive psychological …
Genetics of nonsyndromic orofacial clefts
F Rahimov, A Jugessur… - The Cleft palate …, 2012 - journals.sagepub.com
With an average worldwide prevalence of approximately 1.2/1000 live births, orofacial clefts
are the most common craniofacial birth defects in humans. Like other complex disorders …
are the most common craniofacial birth defects in humans. Like other complex disorders …
Genetics and signaling mechanisms of orofacial clefts
Craniofacial development involves several complex tissue movements including several
fusion processes to form the frontonasal and maxillary structures, including the upper lip and …
fusion processes to form the frontonasal and maxillary structures, including the upper lip and …
Genetics of cleft lip and palate: syndromic genes contribute to the incidence of non-syndromic clefts
P Stanier, GE Moore - Human molecular genetics, 2004 - academic.oup.com
Clefts of the lip and/or palate (CL/P) are among the most common birth defects worldwide.
The majority are non-syndromic where CL/P occurs in isolation of other phenotypes. Where …
The majority are non-syndromic where CL/P occurs in isolation of other phenotypes. Where …
The genetics and epigenetics of orofacial clefts
RA Spritz - Current opinion in pediatrics, 2001 - journals.lww.com
Orofacial clefts (cleft lip, cleft palate) are among the most common of all major birth defects,
but very little is known about their causation. Genetic factors are thought to play a major role …
but very little is known about their causation. Genetic factors are thought to play a major role …
Genetics of cleft lip and cleft palate
EJ Leslie, ML Marazita - … Journal of Medical Genetics Part C …, 2013 - Wiley Online Library
Orofacial clefts are common birth defects and can occur as isolated, nonsyndromic events or
as part of Mendelian syndromes. There is substantial phenotypic diversity in individuals with …
as part of Mendelian syndromes. There is substantial phenotypic diversity in individuals with …
Spectrum of dental phenotypes in nonsyndromic orofacial clefting
BJ Howe, ME Cooper, AR Vieira… - Journal of dental …, 2015 - journals.sagepub.com
Children with oral clefts show a wide range of dental anomalies, adding complexity to
understanding the phenotypic spectrum of orofacial clefting. The evidence is mixed …
understanding the phenotypic spectrum of orofacial clefting. The evidence is mixed …
Genetic factors and orofacial clefting
AC Lidral, LM Moreno, SA Bullard - Seminars in orthodontics, 2008 - Elsevier
Cleft lip with or without cleft palate is the most common facial birth defect and it is caused by
a complex interaction between genetic and environmental factors. The purpose of this …
a complex interaction between genetic and environmental factors. The purpose of this …