The invasiveness of human intracranial tumours was studied in an organ culture system.
Biopsies from six glioblastomas, four astrocytomas, two mixed gliomas, one ependymoma …

The in vitro invasive growth of two continuous human glioma cell lines (D-54Mg and GaMg)
into aggregates of fetal rat brain cells is described. The tumor cells were first cultured as …

Invasion of spheroids from 20 human primary glioblastomas into precultured fetal rat brain
tissue in culture has been studied and quantified. Between 30 and 98 percent of the normal …

Two malignant rat neurogenic cell lines have been confronted with reaggregation cultures of
fetal rat brain in a stationary culture system. In this organ culture system several …

Malignant human glioma is characterized by an uncontrolled cell proliferation and infiltrative
growth into the brain. The mechanisms by which invasion occurs are poorly understood …

A system for coculture between normal rat brain fragments and multicellular spheroids of rat
glioma cells is described. The tumor cells were derived from fetal BD IX rats treated …

Five established cell lines derived from human anaplastic astrocytomas or glioblastoma
multiforme were tested for invasiveness into precultured chick heart fragments in vitro. Four …

Scanning electron microscopy was employed to investigate cocultures between normal rat
brain fragments and spheroids consisting of rat glioma cells. Lamellipodia were seen to …

✓ Brain invasion prevents complete surgical extirpation of malignant gliomas; however,
invasive cells from distant, histologically normal brain previously have not been isolated …

✓ Embryonic chick heart fragments were confronted in vitro with cells from 26 freshly
resected human brain tumors. The tumor-derived cells were scored according to their …