The hypothalamic-pituitary-adrenal axis in PTSD: Pathophysiology and treatment interventions

BW Dunlop, A Wong - Progress in Neuro-psychopharmacology and …, 2019 - Elsevier
Questions of how altered functioning of the hypothalamic pituitary adrenal (HPA) axis
contribute to the development and maintenance of posttraumatic stress disorder (PTSD) …

Neuroendocrine aspects of PTSD

R Yehuda - Anxiety and anxiolytic drugs, 2005 - Springer
This chapter discussed how neuroendocrine findings in posttraumatic stress disorder
(PTSD) potentially inform hypothalamic-pituitary-adrenal (HPA) alterations in PTSD and …

Hypothalamic-pituitary-adrenal dysfunction in posttraumatic stress disorder

R Yehuda, EL Giller, SM Southwick, MT Lowy… - Biological …, 1991 - Elsevier
Neuroendocrine studies examining the hypothalamic-pituitary-adrenal (HPA) axis under
baseline conditions and in response to neuroendocrine challenges have supported the …

Predicting PTSD prospectively based on prior trauma history and immediate biological responses

DL Delahanty, NR Nugent - Annals of the New York Academy …, 2006 - Wiley Online Library
Studies examining the biopsychology of posttraumatic stress disorder (PTSD) have
suggested that PTSD is characterized by alterations of the primary stress pathways: the …

Current status of cortisol findings in post-traumatic stress disorder

R Yehuda - Psychiatric Clinics, 2002 - psych.theclinics.com
The majority of studies of post-traumatic stress disorder (PTSD) demonstrate alterations
consistent with an enhanced negative feedback inhibition of cortisol on the pituitary and an …

Assessment of HPA-axis function in posttraumatic stress disorder: pharmacological and non-pharmacological challenge tests, a review

CS De Kloet, E Vermetten, E Geuze… - Journal of psychiatric …, 2006 - Elsevier
Posttraumatic stress disorder (PTSD) is typically accompanied by acute and chronic
alterations in the stress response. These alterations have mostly been described in …

Cortisol response to a cognitive stress challenge in posttraumatic stress disorder (PTSD) related to childhood abuse

JD Bremner, M Vythilingam, E Vermetten, J Adil… - …, 2003 - Elsevier
Preclinical studies show that animals with a history of chronic stress exposure have
increased hypothalamic-pituitary-adrenal (HPA) axis reactivity following reexposure to …

Implications of hypothalamic–pituitary–adrenal axis functioning in posttraumatic stress disorder

T Jones, MD Moller - Journal of the American Psychiatric …, 2011 - journals.sagepub.com
Background: Cortisol secretions serve as the barometer of the hypothalamic–pituitary–
adrenal (HPA) axis, which regulates and controls responses to stress. Studies of cortisol …

Neuroendocrinology of post-traumatic stress disorder

P Pervanidou, GP Chrousos - Progress in brain research, 2010 - Elsevier
Dysregulation of the stress system, including the hypothalamic–pituitary–adrenal (HPA) axis
and the locus caeruleus/norepinephrine–sympathetic nervous system (SNS), is involved in …

Biology of posttraumatic stress disorder

R Yehuda - Journal of Clinical Psychiatry, 2001 - psychiatrist.com
Most biological findings in posttraumatic stress disorder (PTSD) are compatible with those of
the chronic stress response, such as increased corticotropin-releasing factor (CRF) …