Beneficial effects of ischemic preconditioning on pancreas cold preservation

AR Hogan, M Doni, RD Molano… - Cell …, 2012 - journals.sagepub.com
Ischemic preconditioning (IPC) confers tissue resistance to subsequent ischemia in several
organs. The protective effects are obtained by applying short periods of warm ischemia …

Ischemic preconditioning improves islet recovery after pancreas cold preservation

AR Hogan, M Doni, MM Ribeiro, RD Molano… - Transplantation …, 2009 - Elsevier
Increasing evidence supports the beneficial effects of ischemic preconditioning (IPC) of
organs on subsequent ischemia. The aim of this study was to assess the effects of IPC of the …

Ischemic preconditioning fails to improve microcirculation but increases apoptotic cell death in experimental pancreas transplantation

O Drognitz, X Liu, R Obermaier, H Neeff… - Transplant …, 2004 - Wiley Online Library
Brief periods of warm ischemia and subsequent short reperfusion before either long‐term
cold or warm ischemic insult (ischemic preconditioning, IPC) have proven to ameliorate …

Effects of pancreas cold ischemia on islet function and quality

A Pileggi, MM Ribeiro, AR Hogan, RD Molano… - Transplantation …, 2009 - Elsevier
We used a rat model of pancreas cold preservation to assess its effects on islets. Glands
were surgically retrieved and stored in University of Wisconsin (UW) solution for 3 hours …

Impact of pancreatic cold preservation on rat islet recovery and function

A Pileggi, MM Ribeiro, AR Hogan, RD Molano… - …, 2009 - journals.lww.com
Background. Islet transplantation success depends on the number and quality of islets
transplanted. This study aimed at exploring the molecular mechanisms associated with cold …

Mechanisms of islet damage mediated by pancreas cold ischemia/rewarming

K Omori, E Kobayashi, J Rawson, M Takahashi… - Cryobiology, 2016 - Elsevier
Prolonged pancreas cold ischemia is known to negatively correlate with islet isolation
outcomes, hindering successful islet transplantation to treat Type-1 Diabetes. Due to poor …

Ischemic preconditioning and liver tolerance to warm or cold ischemia: experimental studies in large animals

P Compagnon, S Lindell, MS Ametani, B Gilligan… - …, 2005 - journals.lww.com
Background. In the rodent, ischemic preconditioning (IPC) has been shown to improve the
tolerance of the liver to ischemia-reperfusion under normothermic or hypothermic conditions …

Heat shock preconditioning impairs revascularization of freely transplanted pancreatic islets1

R Schramm, C Scheuer, J Yamauchi, B Vollmar… - …, 2002 - journals.lww.com
Background. Revascularization of freely transplanted pancreatic islets is essential for
appropriate graft function and survival. During the first days after transplantation, however …

Ischemic preconditioning in a rodent hepatocyte model of liver hypothermic preservation injury

P Compagnon, HB Wang, JH Southard, MJ Mangino - Cryobiology, 2002 - Elsevier
Ischemic preconditioning (IPC) is a phenomenon of protection in various tissues from
normothermic ischemic injury by previous exposure to short cycles of ischemia–reperfusion …

Hypothermic perfusion preservation of pancreas for islet grafts: validation using a split lobe porcine model

BP Weegman, MJ Taylor, SC Baicu, WE Scott… - 2011 - journals.sagepub.com
The demand for high-quality islets for transplantation in type I diabetics will increase as the
current clinical trials transition into standard of care. The mode of preservation of donor …