Comparison of two behavioral tests for tinnitus assessment in mice

EM Fabrizio-Stover, G Nichols, J Corcoran… - Frontiers in behavioral …, 2022 - frontiersin.org
Animal research focused on chronic tinnitus associated with noise-induced hearing loss can
be expensive and time-consuming as a result of the behavioral training required. Although …

A conditioned behavioral paradigm for assessing onset and lasting tinnitus in rats

E Pace, H Luo, M Bobian, A Panekkad, X Zhang… - PLoS …, 2016 - journals.plos.org
Numerous behavioral paradigms have been developed to assess tinnitus-like behavior in
animals. Nevertheless, they are often limited by prolonged training requirements, as well as …

Development of tinnitus in CBA/CaJ mice following sound exposure

RJ Longenecker, AV Galazyuk - Journal of the Association for Research in …, 2011 - Springer
Tinnitus, the perception of a sound without an external acoustic source, is a complex
perceptual phenomenon affecting the quality of life in 17% of the adult population. Despite …

Psychophysical and neural correlates of noised-induced tinnitus in animals: Intra-and inter-auditory and non-auditory brain structure studies

J Zhang, H Luo, E Pace, L Li, B Liu - Hearing research, 2016 - Elsevier
Tinnitus, a ringing in the ear or head without an external sound source, is a prevalent health
problem. It is often associated with a number of limbic-associated disorders such as anxiety …

Using an appetitive operant conditioning paradigm to screen rats for tinnitus induced by intense sound exposure: Experimental considerations and interpretation

SH Hayes, K Beh, M Typlt, AL Schormans… - Frontiers in …, 2023 - frontiersin.org
In an effort to help elucidate the neural mechanisms underlying tinnitus in humans,
researchers have often relied on animal models; a preclinical approach which ultimately …

Mice prone to tinnitus after acoustic trauma show increased pre-exposure sensitivity to background noise

N Rybalko, Š Suchánková, Z Bureš… - Frontiers in Behavioral …, 2023 - frontiersin.org
Noise-induced tinnitus is generally associated with hearing impairment caused by traumatic
acoustic overexposure. Previous studies in laboratory animals and human subjects …

An operant-based detection method for inferring tinnitus in mice

H Zuo, D Lei, S Sivaramakrishnan, B Howie… - Journal of neuroscience …, 2017 - Elsevier
Background Subjective tinnitus is a hearing disorder in which a person perceives sound
when no external sound is present. It can be acute or chronic. Because our current …

Variable effects of acoustic trauma on behavioral and neural correlates of tinnitus in individual animals

RJ Longenecker, AV Galazyuk - Frontiers in behavioral neuroscience, 2016 - frontiersin.org
The etiology of tinnitus is known to be diverse in the human population. An appropriate
animal model of tinnitus should incorporate this pathological diversity. Previous studies …

Spontaneous behavior in noise and silence: a possible new measure to assess tinnitus in guinea pigs

AN Heeringa, MJH Agterberg, P van Dijk - Frontiers in Neurology, 2014 - frontiersin.org
This study describes two experiments that were conducted in search for a behavioral
paradigm to test for tinnitus in guinea pigs. Conditioning paradigms are available to …

Age effects on tinnitus and hearing loss in CBA/CaJ mice following sound exposure

RJ Longenecker, KT Chonko, SM Maricich… - Springerplus, 2014 - Springer
Tinnitus is a maladaptive neuropathic condition that develops in humans and laboratory
animals following auditory insult. In our previous study we demonstrated that sound …