The stabilization of protein–protein interactions (PPIs) has emerged as a promising strategy
in chemical biology and drug discovery. The identification of suitable starting points for …

Modulation of protein–protein interactions (PPIs) by small molecules has emerged as a
valuable approach in drug discovery. Compared to direct inhibition, PPI stabilization is vastly …

Molecules that stabilize protein–protein interactions (PPIs) are invaluable as tool
compounds for biophysics and (structural) biology, and as starting points for molecular glue …

Dysregulation of protein–protein interactions (PPIs) commonly leads to disease. PPI
stabilization has only recently been systematically explored for drug discovery despite being …

Small‐molecule stabilization of protein‐protein interactions (PPIs) is a promising strategy in
chemical biology and drug discovery. However, the systematic discovery of PPI stabilizers …

The stabilization of protein complexes has emerged as a promising modality, expanding the
number of entry points for novel therapeutic intervention. Targeting proteins that mediate …

The systematic stabilization of protein–protein interactions (PPI) has great potential as
innovative drug discovery strategy to target novel and hard-to-drug protein classes. The …

Protein–protein interactions (PPIs) of 14‐3‐3 proteins are a model system for studying PPI
stabilization. The complex natural product Fusicoccin A stabilizes many 14‐3‐3 PPIs but is …

A cooperativity framework to describe and interpret small-molecule stabilization of protein–
protein interactions (PPI) is presented. The stabilization of PPIs is a versatile and emerging …

Protein–protein interactions (PPIs) are at the core of molecular control over cellular function.
Multivalency in PPI formation, such as via proteins with multiple binding sites and different …