Context: Combined pituitary hormone deficiency (CPHD) is characterized by deficiencies in
more than one anterior pituitary hormone. Mutations in developmental factors responsible …

Development of the pituitary gland and pituitary cell determination and specification depend
on the expression and interaction of signaling molecules and transcription factors in …

This review will address contributions of nuclear transcription factors to the embryologic
development and definitive function of the anterior pituitary gland. The HESX1, PITX1 …

Mechanisms that control pituitary development are gradually better understood. They
involve molecular signals from surrounding structures and the expression of a cascade of …

Normal hypothalamopituitary development is closely related to that of the forebrain and is
dependent upon a complex genetic cascade of transcription factors and signaling molecules …

Recent advances in our knowledge of pituitary development, acquired mainly from animal
models, have enhanced our understanding of the aetiology of isolated growth hormone …

Defects in pituitary gland organogenesis are sometimes associated with congenital
anomalies that affect head development. Lesions in transcription factors and signaling …

Objective: Mutations in the genes encoding pituitary transcription factors (mainly PROP1,
POUF1 and HESX1) are responsible for familial combined pituitary hormone deficiency …

Research over the last 20 years has led to the elucidation of the genetic aetiologies of
Isolated Growth Hormone Deficiency (IGHD) and Combined Pituitary Hormone Deficiency …

Deficiencies in the homeobox transcription factors LHX4 and PROP1 cause pituitary
hormone deficiency in both humans and mice. Lhx4 and Prop1 mutants exhibit severe …