Many aspects of pituitary development have become better understood in the past two
decades. The signaling pathways regulating pituitary growth and shape have emerged, and …

Introduction: Congenital hypopituitarism (CH) is characterized by a deficiency of one or more
pituitary hormones. The pituitary gland is a central regulator of growth, metabolism, and …

The pituitary gland and the hypothalamus are morphologically and functionally associated in
the endocrine and neuroendocrine control of other endocrine glands. They therefore play a …

Anterior pituitary agenesis (APA) has very rarely been reported. Therefore, its phenotypical
and genotypical features are not well known. The aim of this study was to ascertain whether …

The hypothalamus integrates physiological processes essential for survival and
reproduction. Recent studies have shown that developmental events can affect these …

Objectives: To investigate the prevalence of pituitary stalk dysgenesis (PSD) in adult
hypopituitary patients by describing the chronology of hormone deficiencies and their …

Abstract Background/Aims: Mutation frequencies of genes involved in combined pituitary
hormone deficiency (CPHD) vary substantially between populations. The HYPOPIT study …

Background/Aims: Many genes encoding pituitary transcription factors involved in the
formation of the pituitary gland are identified. Different mutations in these genes have been …

As pituitary function depends on the integrity of the hypothalamic-pituitary axis, any defect in
the development and organogenesis of this gland may account for a form of combined …

Over the last 5 years, new actors involved in the pathogenesis of combined pituitary
hormone deficiency in humans have been reported: they included a member of the …