The present study focused on the evaluation of nicotine abstinence syndrome in mice and
on the influence of calcium channel blockers on the expression of the somatic signs of …

Recently, a rodent model of nicotine abstinence syndrome has been developed based on
observing the frequency of spontaneous behavioral signs following termination of …

Rationale The ability of nicotine to induce dependence (result in a withdrawal syndrome) is
typically thought to require long-term, daily smoking. Emerging evidence suggests that …

Smoking is a widespread health problem. Because the nicotine withdrawal syndrome is a
major contributor to continued smoking and relapse, it is important to understand the …

Previous studies of human cigarette smoking have shown that administration of the nicotinic
acetylcholine receptor antagonist mecamylamine produces acute increases in smoking …

The nicotine withdrawal syndrome was validated and characterized in the mouse using both
somatic and affective measures after infusion with nicotine daily via subcutaneous …

Mecamylamine, a noncompetitive nicotinic cholinergic antagonist, inhibits nicotine self-
administration in animals and may attenuate tobacco smoking in humans trying to quit. Our …

Separate and combined effects of nicotine and the nicotinic antagonist mecamylamine were
studied in 32 healthy volunteer smokers after overnight abstinence from smoking. Subjects …

Background Nonsomatic signs of psychostimulant withdrawal, difficult to demonstrate in
animal paradigms, may appear to promote drug seeking and drug relapse in humans; thus …

Nicotine-withdrawal after daily exposure manifests somatic and affective symptom including
a range of cognitive deficits. Earlier studies suggested participation of L-type calcium …