Neurodegeneration in an animal model of Parkinson's disease is exacerbated by a high-fat diet
JK Morris, GL Bomhoff, JA Stanford… - American Journal of …, 2010 - journals.physiology.org
Despite numerous clinical studies supporting a link between type 2 diabetes (T2D) and
Parkinson's disease (PD), the clinical literature remains equivocal. We, therefore, sought to …
Parkinson's disease (PD), the clinical literature remains equivocal. We, therefore, sought to …
Insulin resistance impairs nigrostriatal dopamine function
JK Morris, GL Bomhoff, BK Gorres, VA Davis, J Kim… - Experimental …, 2011 - Elsevier
Clinical studies have indicated a link between Parkinson's disease (PD) and Type 2
Diabetes. Although preclinical studies have examined the effect of high-fat feeding on …
Diabetes. Although preclinical studies have examined the effect of high-fat feeding on …
Measures of striatal insulin resistance in a 6-hydroxydopamine model of Parkinson's disease
JK Morris, H Zhang, AA Gupte, GL Bomhoff… - Brain research, 2008 - Elsevier
Clinical evidence has shown a correlation between Parkinson's disease (PD) and Type 2
Diabetes (T2D), as abnormal glucose tolerance has been reported in> 50% of PD patients …
Diabetes (T2D), as abnormal glucose tolerance has been reported in> 50% of PD patients …
[HTML][HTML] High-fat diet-induced diabetes leads to vascular alterations, pericyte reduction, and perivascular depletion of microglia in a 6-OHDA toxin model of Parkinson …
OF Elabi, JPMCM Cunha, A Gaceb, M Fex… - Journal of …, 2021 - Springer
Background Diabetes has been recognized as a risk factor contributing to the incidence and
progression of Parkinson's disease (PD). Although several hypotheses suggest a number of …
progression of Parkinson's disease (PD). Although several hypotheses suggest a number of …
Metabolic inflammation exacerbates dopaminergic neuronal degeneration in response to acute MPTP challenge in type 2 diabetes mice
L Wang, YQ Zhai, LL Xu, C Qiao, XL Sun, JH Ding… - Experimental …, 2014 - Elsevier
Abstract Parkinson's disease (PD), one of the most common neurodegenerative diseases, is
characterized by the loss of dopaminergic neurons in the substantia nigra. Increasing …
characterized by the loss of dopaminergic neurons in the substantia nigra. Increasing …
[HTML][HTML] High fat diet suppresses peroxisome proliferator-activated receptors and reduces dopaminergic neurons in the substantia nigra
YC Kao, WY Wei, KJ Tsai, LC Wang - International journal of molecular …, 2019 - mdpi.com
Although several epidemiologic and animal studies have revealed correlations between
obesity and neurodegenerative disorders, such as Parkinson disease (PD), the underlying …
obesity and neurodegenerative disorders, such as Parkinson disease (PD), the underlying …
High-fat diet exacerbates MPTP-induced dopaminergic degeneration in mice
The identification of modifiable nutritional risk factors is highly relevant to the development of
preventive strategies for neurodegenerative disorders including Parkinson's disease (PD). In …
preventive strategies for neurodegenerative disorders including Parkinson's disease (PD). In …
Diabetes causes dysfunctional dopamine neurotransmission favoring nigrostriatal degeneration in mice
I Pérez‐Taboada, S Alberquilla, ED Martín… - Movement …, 2020 - Wiley Online Library
Background Numerous studies indicate an association between neurodegenerative and
metabolic diseases. Although still a matter of debate, growing evidence from …
metabolic diseases. Although still a matter of debate, growing evidence from …
Dietary restriction and 2‐deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic neurons in models of Parkinson's …
W Duan, MP Mattson - Journal of neuroscience research, 1999 - Wiley Online Library
Parkinson's disease (PD) is an age‐related disorder characterized by progressive
degeneration of dopaminergic neurons in the substantia nigra (SN) and corresponding …
degeneration of dopaminergic neurons in the substantia nigra (SN) and corresponding …
Exercise induces behavioral recovery and attenuates neurochemical deficits in rodent models of Parkinson's disease
Exercise is thought to improve motor function and emotional well-being in patients with
Parkinson's disease (PD). However, it is not clear if the improvements are due to …
Parkinson's disease (PD). However, it is not clear if the improvements are due to …
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