Kallikrein is a proteolytic enzyme(EC 3.4. 2 1.8) which specifically splits its natural substrate,
kininogen, a plasma a2-globulin. Kallikrein acts on its substrate by cleaving off a peptide, a …

Accumulating evidence has highlighted the importance of the KKS as a protective system
against oxidative stress and organ damage in the heart and kidney. The activation of the …

High molecular weight kininogen (HK) is a plasma protein that is cleaved by plasma
kallikrein in the clinical settings of sepsis and chronic inflammatory diseases such as …

Human tissue kallikrein gene polymorphisms were identified in the promoter region by
polymerase chain reaction (PCR) and DNA sequencing. One polymorphic region was …

Tissue kallikrein exerts various biological functions through kinin formation with subsequent
kinin B2 receptor activation. Recent studies showed that tissue kallikrein directly activates …

Publisher Summary This chapter focuses primarily on the molecular biology of the tissue
kallikrein (KLK) gene family. The chapter emphasizes on the differences in gene structure …

Kinins are a group of peptides released in blood and tissues by the action of trypsin-like
endopeptidases, the kallikreins. A variety of stimuli have been shown to transform the …

Brown Norway kininogen-deficient rats had very low levels of plasma kininogens and lower
levels of plasma prekallikrein, compared with those of normal rats of the same strain …

The renal kallikrein–kinin system is involved in sodium and water homeostasis, blood
pressure regulation and inflammation. Tissue kallikrein and kinin levels were measured in …

The urinary excretion of kallikrein, an enzyme which cleaves a vasodilator kinin from
kininogen substrate, was examined in three types of hypertensive rats. Enzyme activity was …