Exosomes and immune response in cancer: friends or foes?

FM Barros, F Carneiro, JC Machado… - Frontiers in …, 2018 - frontiersin.org
Exosomes are a type of extracellular vesicle whose study has grown exponentially in recent
years. This led to the understanding that these structures, far from being inert waste by …

Exosome-based immunotherapy: a promising approach for cancer treatment

Z Xu, S Zeng, Z Gong, Y Yan - Molecular cancer, 2020 - Springer
In the era of the rapid development of cancer immunotherapy, there is a high level of interest
in the application of cell-released small vesicles that stimulate the immune system. As cell …

Exosomes, their biogenesis and role in inter-cellular communication, tumor microenvironment and cancer immunotherapy

KK Jella, TH Nasti, Z Li, SR Malla, ZS Buchwald… - Vaccines, 2018 - mdpi.com
Exosomes are extracellular vesicles ranging from 30 to 150 nm in diameter that contain
molecular constituents of their host cells. They are released from different types of cells …

The function and clinical application of extracellular vesicles in innate immune regulation

X Zhou, F Xie, L Wang, L Zhang, S Zhang… - Cellular & molecular …, 2020 - nature.com
The innate immune system plays a crucial role in the host defense against viral and
microbial infection. Exosomes constitute a subset of extracellular vesicles (EVs) that can be …

Roles of exosomes in immunotherapy for solid cancers

C Lyu, H Sun, Z Sun, Y Liu, Q Wang - Cell Death & Disease, 2024 - nature.com
Although immunotherapy has made breakthrough progress, its efficacy in solid tumours
remains unsatisfactory. Exosomes are the main type of extracellular vesicles that can deliver …

Harnessing the exosome-induced immune response for cancer immunotherapy

U Gehrmann, TI Näslund, S Hiltbrunner… - Seminars in Cancer …, 2014 - Elsevier
In recent years exosomes have emerged as potent stimulators of immune responses and as
agents for cancer therapy. Exosomes can carry a broad variety of immunostimulatory …

Recent advances in exosome-based immunotherapy applied to cancer

J Xie, Z Zheng, L Tuo, X Deng, H Tang… - Frontiers in …, 2023 - frontiersin.org
Cancer stands as a prominent contributor to global mortality rates, necessitating immediate
attention toward the exploration of its treatment options. Extracellular vesicles have been …

Exosomes and their roles in immune regulation and cancer

DW Greening, SK Gopal, R Xu, RJ Simpson… - Seminars in cell & …, 2015 - Elsevier
Exosomes, a subset of extracellular vesicles (EVs), function as a mode of intercellular
communication and molecular transfer. Exosomes facilitate the direct extracellular transfer of …

Extracellular vesicles in cancer immune microenvironment and cancer immunotherapy

F Xie, X Zhou, M Fang, H Li, P Su, Y Tu… - Advanced …, 2019 - Wiley Online Library
Extracellular vesicles (EVs) are secreted by almost all cells. They contain proteins, lipids,
and nucleic acids which are delivered from the parent cells to the recipient cells. Thereby …

The distinct roles of exosomes in innate immune responses and therapeutic applications in cancer

J Rezaie, T Etemadi, M Feghhi - European journal of pharmacology, 2022 - Elsevier
The innate immune system is one of the major constituents of the host's defense against
invading pathogens and extracellular vesicles (EVs) are involved in regulating its …