[HTML][HTML] Transcriptome-wide analysis of alternative routes for RNA substrates into the exosome complex
C Delan-Forino, C Schneider, D Tollervey - PLoS genetics, 2017 - journals.plos.org
The RNA exosome complex functions in both the accurate processing and rapid
degradation of many classes of RNA. Functional and structural analyses indicate that RNA …
degradation of many classes of RNA. Functional and structural analyses indicate that RNA …
The Rrp6 C-terminal domain binds RNA and activates the nuclear RNA exosome
EV Wasmuth, CD Lima - Nucleic acids research, 2017 - academic.oup.com
The eukaryotic RNA exosome is an essential, multi-subunit complex that catalyzes RNA
turnover, maturation, and quality control processes. Its non-catalytic donut-shaped core …
turnover, maturation, and quality control processes. Its non-catalytic donut-shaped core …
Genome-wide analysis reveals distinct substrate specificities of Rrp6, Dis3, and core exosome subunits
DL Kiss, ED Andrulis - Rna, 2010 - rnajournal.cshlp.org
The RNA processing exosome complex was originally defined as an evolutionarily
conserved multisubunit complex of ribonucleases responsible for the processing and/or …
conserved multisubunit complex of ribonucleases responsible for the processing and/or …
[HTML][HTML] The RNA exosome channeling and direct access conformations have distinct in vivo functions
J Han, A van Hoof - Cell reports, 2016 - cell.com
The RNA exosome is a 3′–5′ ribonuclease complex that is composed of nine core
subunits and an essential catalytic subunit, Rrp44. Two distinct conformations of Rrp44 were …
subunits and an essential catalytic subunit, Rrp44. Two distinct conformations of Rrp44 were …
[HTML][HTML] Threading the barrel of the RNA exosome
C Schneider, D Tollervey - Trends in biochemical sciences, 2013 - cell.com
In eukaryotes, the exosome complex degrades RNA backbones and plays key roles in RNA
processing and surveillance. It was predicted that RNA substrates are threaded through a …
processing and surveillance. It was predicted that RNA substrates are threaded through a …
[HTML][HTML] Transcriptome-wide analysis of exosome targets
The exosome plays major roles in RNA processing and surveillance but the in vivo target
range and substrate acquisition mechanisms remain unclear. Here we apply in vivo RNA …
range and substrate acquisition mechanisms remain unclear. Here we apply in vivo RNA …
The eukaryotic RNA exosome
K Januszyk, CD Lima - Current opinion in structural biology, 2014 - Elsevier
Highlights•Eukaryotic exosome cores and phosphorolytic exoribonucleases are structurally
similar.•Exosome cores include a central channel but are catalytically inert.•Central channel …
similar.•Exosome cores include a central channel but are catalytically inert.•Central channel …
Targeting RNA for processing or destruction by the eukaryotic RNA exosome and its cofactors
The eukaryotic RNA exosome is an essential and conserved protein complex that can
degrade or process RNA substrates in the 3′-to-5′ direction. Since its discovery nearly …
degrade or process RNA substrates in the 3′-to-5′ direction. Since its discovery nearly …
The RNA exosome shapes the expression of key protein-coding genes
M Wu, E Karadoulama, M Lloret-Llinares… - Nucleic acids …, 2020 - academic.oup.com
The ribonucleolytic exosome complex is central for nuclear RNA degradation, primarily
targeting non-coding RNAs. Still, the nuclear exosome could have protein-coding (pc) gene …
targeting non-coding RNAs. Still, the nuclear exosome could have protein-coding (pc) gene …
[HTML][HTML] Extensive degradation of RNA precursors by the exosome in wild-type cells
RK Gudipati, Z Xu, A Lebreton, B Séraphin… - Molecular cell, 2012 - cell.com
The exosome is a complex involved in the maturation of rRNA and sn-snoRNA, in the
degradation of short-lived noncoding RNAs, and in the quality control of RNAs produced in …
degradation of short-lived noncoding RNAs, and in the quality control of RNAs produced in …