■ Despite the fact that presumably a high variety of different phenomena contribute to the
pathogenesis of OA, premature aging of the chondrocytes and the matrix presumably plays …

Osteoarthritis (OA) is characterized by a degeneration of articular cartilage, in which the
breakdown leads to matrix fibrillation, fissure appearance, gross ulceration, and fullthickness …

Osteoarthritis (OA) is defined by the American College of Rheumatology as a
“heterogeneous group of conditions that lead to joint symptoms and signs which are …

Striking features of osteoarthritis (OA) include its association with increasing age,
relationship to mechanically deranged joints and the prominent destruction of load-bearing …

The traditional view of OA is that it is primarily a disease of articular cartilage that results, by
altering the biomechanics of the joint, in secondary changes to the subchondral bone and …

[Frontiers in Bioscience 4, d662-670, October 15, 1999] 662 An introduction to the pathophysiology
of osteoarthritis A. Robin Po Page 1 [Frontiers in Bioscience 4, d662-670, October 15, 1999] …

Osteoarthritis (OA) is a disease mostly characterized by biochemical, physical and
histological abnormalities of cartilage. Hence, the term osteoarthrosis has been preferred by …

The prior notion of osteoarthritis (OA) as a bland disease related to aging and ''wear and
tear''of the joint has given way to views of a dynamic system with multiple pathogenic …

Osteoarthritis (OA) is the most common form of arthritis and a major cause of pain and
disability in older adults (1). Often OA is referred to as degenerative joint disease “(DJD)” …

osteoarthritis is the most prevalent form of arthritis in the world. With the progressive ageing
of the population, it becomes a major problem of public health. Osteoarthritis is a …