There are now nearly 300 single-gene inborn errors of immunity underlying phenotypes as
diverse as infection, malignancy, allergy, auto-immunity, and auto-inflammation. For each of …

Since the 1990s, the International Union of Immunological Societies (IUIS) PID expert
committee (EC), now called Inborn Errors of Immunity Committee, has published every other …

The number of genetically defined Primary Immunodeficiency Diseases (PID) has increased
exponentially, especially in the past decade. The biennial classification published by the …

We report the updated classification of primary immunodeficiencies compiled by the Primary
Immunodeficiency Expert Committee (PID EC) of the International Union of Immunological …

Primary immunodeficiencies (PIDs) are rare monogenic inborn errors of immunity that result
in impairment of functions of the human immune system. PIDs have a broad phenotype with …

We report the updated classification of primary immunodeficiencies (PIDs) compiled by the
Expert Committee of the International Union of Immunological Societies. In comparison to …

Abstract Since 2013, the International Union of Immunological Societies (IUIS) expert
committee (EC) on Inborn Errors of Immunity (IEI) has published an updated phenotypic …

Background Recently, a growing number of novel genetic defects underlying primary
immunodeficiencies (PIDs) have been identified, increasing the number of PID up to more …

Beginning in 1970, a committee was constituted under the auspices of the World Health
Organization (WHO) to catalog primary immunodeficiencies. Twenty years later, the …

A recent surge in newly described primary immunodeficiencies (PIDs) has highlighted new
physiological and pathophysiological pathways that affect the immune system. Furthermore …