Key Principles and Clinical Applications of “Next-Generation” DNA Sequencing

JM Rizzo, MJ Buck - Cancer prevention research, 2012 - AACR
Demand for fast, inexpensive, and accurate DNA sequencing data has led to the birth and
dominance of a new generation of sequencing technologies. So-called “next-generation” …

[PDF][PDF] Generations of sequencing technologies: from first to next generation

M Kchouk, JF Gibrat, M Elloumi - Biology and Medicine, 2017 - edisciplinas.usp.br
DNA sequencing process utilizes biochemical methods in order to determine the correct
order of nucleotide bases in a DNA macromolecule using sequencing machines. Ten years …

Massively parallel sequencing techniques for forensics: A review

B Bruijns, R Tiggelaar, H Gardeniers - Electrophoresis, 2018 - Wiley Online Library
DNA sequencing, starting with Sanger's chain termination method in 1977 and evolving into
the next generation sequencing (NGS) techniques of today that employ massively parallel …

Massively parallel sequencing: the next big thing in genetic medicine

T Tucker, M Marra, JM Friedman - The American Journal of Human …, 2009 - cell.com
Massively parallel sequencing has reduced the cost and increased the throughput of
genomic sequencing by more than three orders of magnitude, and it seems likely that costs …

Perspectives and challenges of emerging single‐molecule DNA sequencing technologies

M Xu, D Fujita, N Hanagata - Small, 2009 - Wiley Online Library
The growing demand for analysis of the genomes of many species and cancers, for
understanding the role of genetic variation among individuals in disease, and with the …

A glimpse into past, present, and future DNA sequencing

M Morey, A Fernández-Marmiesse… - Molecular genetics and …, 2013 - Elsevier
Current advances in DNA sequencing technologies are dropping down sequencing cost
while increasing throughput at a pace never shown before. Past-decade great milestones …

Massively parallel sequencing: the new frontier of hematologic genomics

JM Johnsen, DA Nickerson… - Blood, The Journal of the …, 2013 - ashpublications.org
Genomic technologies are becoming a routine part of human genetic analysis. The
exponential growth in DNA sequencing capability has brought an unprecedented …

The application of long-read sequencing in clinical settings

JB Oehler, H Wright, Z Stark, AJ Mallett, U Schmitz - Human genomics, 2023 - Springer
Long-read DNA sequencing technologies have been rapidly evolving in recent years, and
their ability to assess large and complex regions of the genome makes them ideal for clinical …

Human genome sequencing at the population scale: a primer on high-throughput DNA sequencing and analysis

RL Goldfeder, DP Wall, MJ Khoury… - American journal of …, 2017 - academic.oup.com
Most human diseases have underlying genetic causes. To better understand the impact of
genes on disease and its implications for medicine and public health, researchers have …

Long-read DNA sequencing: recent advances and remaining challenges

PE Warburton, RP Sebra - Annual review of genomics and …, 2023 - annualreviews.org
DNA sequencing has revolutionized medicine over recent decades. However, analysis of
large structural variation and repetitive DNA, a hallmark of human genomes, has been …