Receptor tyrosine kinases (RTKs) are critical for normal cell growth, differentiation, and
development, but they contribute to various pathological conditions when disrupted …

We previously identified intersectin, a multiple EH and SH3 domain-containing protein, as a
component of the endocytic machinery. Overexpression of the SH3 domains of intersectin …

Ubiquitylation of receptor tyrosine kinases plays a critical role in regulating the trafficking
and lysosomal degradation of these important signaling molecules. We identified the …

Intersectin (ITSN) is a molecular scaffold involved in regulating endocytosis and mitogenic
signaling. We previously demonstrated that ITSN transformed rodent fibroblasts, accelerated …

Intersectins (ITSNs) are a family of multi-domain proteins involved in regulation of diverse
cellular pathways. These scaffold proteins are well known for regulating endocytosis but …

Intersectins (ITSNs) represent a family of multi-domain adaptor proteins that regulate
endocytosis and cell signaling. ITSN genes are highly conserved and present in all …

The endocytic pathway is involved in activation and inhibition of cellular signaling. Thus,
defining the regulatory mechanisms that link endocytosis and cellular signaling is of interest …

Intersectin is a member of a growing family of adaptor proteins that possess conserved
Eps15 homology (EH) domains as well as additional protein recognition motifs. In general …

Background Scaffolding proteins of the intersectin (ITSN) family, ITSN1 and ITSN2, are
crucial for the initiation stage of clathrin-mediated endocytosis. These proteins are closely …

While endocytosis attenuates signals from plasma membrane receptors, recent studies
suggest that endocytosis also serves as a platform for the compartmentalized activation of …