To assess involvement of muscarinic cholinergic systems in performance of a shock-
motivated 14-unit T-maze task, 3-month old Fischer-344 rats were given an IP injection of …

Certain antidepressant drugs exert an anxiolytic action in both humans and rodents. The
effects of long-term treatment with imipramine or mirtazapine, two antidepressant drugs with …

Rats exposed to acute unavoidable stress develop a deficit in escaping avoidable aversive
stimuli that lasts as long as unavoidable stress exposure is repeated. A 3‐week exposure to …

Converging evidence indicates that orexins (ORXs), the regulatory neuropeptides, are
implicated in anxiety-and depression-related behaviors via the modulation of …

Behavioral characteristics of the animal models and humans are impaired in chronic stress.
The present study aimed to evaluate and compare the protective effects of sertraline and …

This study tests the hypothesis that the dopaminergic system mediates a restitutive response
by decreasing its own activity in the face of events like persistent inescapable stress that …

Depressive disorder involves emotional, cognitive, autonomic and endocrine alterations and
also evidences support the role of stress in the development of this disorder. Because the …

Chronic mild stress (CMS) has been reported to induce an anhedonic-like state in rats that
resembles some of the symptoms of endogenous depression in humans. In the present …

Major depressive illness is among the most prevalent neuropsychiatric disorders and is
associated with neuroplasticity deficits in limbic structures such as the amygdala. Since …

Stress has a profound impact on the nervous system and causes cognitive problems that are
partly related to the inflammatory effects. Besides influencing the content of …