In vivo and in vitro evaluation of Gd-DTPA-polylysine as a macromolecular contrast agent for magnetic resonance imaging

G SCHUHMANN-GIAMPIERI… - Investigative …, 1991 - journals.lww.com
Polylysine covalently linked to moieties of gadopentelate (Gd-DTPA), for use as a
macromolecular blood pool marker for contrast material-enhanced magnetic resonance …

NMR imaging study of the pharmacodynamics of polylysine-gadolinium-DTPA in the rabbit and the rat

P Van Hecke, G Marchal, H Bosmans… - Magnetic Resonance …, 1991 - Elsevier
The pharmacodynamics of polylysine-(Gd-DTPA)(Schering, Berlin, Germany), a new blood
pooling contrast agent for MRI, were studied in the rabbit and the rat. Polylysine-(Gd-DTPA) …

Effect of varying the molecular weight of the MR contrast agent Gd‐DTPA‐polylysine on blood pharmacokinetics and enhancement patterns

VS Vexler, O Clément… - Journal of Magnetic …, 1994 - Wiley Online Library
The effects of varying the molecular weight of gadolinium‐DTPA (
diethylenetriaminepentaacetic acid)—polylysine, a macromolecular magnetic resonance …

Gd‐DTPA‐cascade‐polymer: potential blood pool contrast agent for MR imaging

G Adam, J Neuerburg, E Spüntrup… - Journal of Magnetic …, 1994 - Wiley Online Library
Abstract Gadolinium‐DTPA (diethylenetriaminepentaacetic acid)‐cascade‐polymer, a
potential new blood pool contrast agent for magnetic resonance (MR) imaging, was …

Albumin labeled with Gd-DTPA: an intravascular contrast-enhancing agent for magnetic resonance blood pool imaging: preparation and characterization

MD Ogan, UDO SCHMIEDL, ME MOSELEY… - Investigative …, 1987 - journals.lww.com
A paramagnetic-labeled macromolecule, albumin-(Gd-DTPA), was prepared for use as an
intravascular contrast agent for magnetic resonance imaging. An average of 19 Gd-DTPA …

[引用][C] Rationale and applications for macromolecular Gd‐based contrast agents

RC Brasch - Magnetic resonance in medicine, 1991 - Wiley Online Library
Macromolecular contrast media (MMCM) for MRI may be defined as paramagnetic or
superparamagnetic compounds of sufficient molecular weight, generally> 20,000 daltons …

Polymeric contrast agents for magnetic resonance imaging: synthesis and characterization of gadolinium diethylenetriaminepentaacetic acid conjugated to …

FE Armitage, DE Richardson, KCP Li - Bioconjugate Chemistry, 1990 - ACS Publications
The synthesis and characterization of polysaccharides esterified with gadolinium
diethylenetriaminepentaacetic acid (GdDTPA) are described. The results of several synthetic …

Synthesis and Characterization of Poly(l-glutamic acid) Gadolinium Chelate:  A New Biodegradable MRI Contrast Agent

X Wen, EF Jackson, RE Price, EE Kim, Q Wu… - Bioconjugate …, 2004 - ACS Publications
Most currently evaluated macromolecular contrast agents for magnetic resonance imaging
(MRI) are not biodegradable. The goal of this study is to synthesize and characterize poly (l …

Evaluation of Gd-DTPA-labeled dextran as an intravascular MR contrast agent: imaging characteristics in normal rat tissues.

SC Wang, MG Wikström, DL White, J Klaveness… - Radiology, 1990 - pubs.rsna.org
Dextran covalently linked to moieties of gadolinium diethylenetriamine pentaacetic acid
(DTPA), for use as a macromolecular, intravascular blood pool marker for contrast material …

Dynamics of tumor imaging with Gd‐DTPA—polyethylene glycol polymers: Dependence on molecular weight

TS Desser, DL Rubin, HH Muller, F Qing… - Journal of Magnetic …, 1994 - Wiley Online Library
Macromolecular contrast media offer potential advantages over freely diffusible agents in
magnetic resonance (MR) imaging outside the central nervous system. To identify an …