Progress and development of carbazole scaffold based as potential anti-alzheimer agents using MTDL approach
Alzheimer's is a neurodegenerative disease (NDs) found in old age people with associated
most common symptom dementia. MTDLs (Multi-Target Direct Ligand strategy) is based on …
most common symptom dementia. MTDLs (Multi-Target Direct Ligand strategy) is based on …
Development of novel carbazole derivatives with effective multifunctional action against Alzheimer's diseases: design, synthesis, in silico, in vitro and in vivo …
Carbazole based novel multifunctional agents has been rationally designed and
synthesized as potential anti-Alzheimer agents. Multi-functional activity of these derivatives …
synthesized as potential anti-Alzheimer agents. Multi-functional activity of these derivatives …
[PDF][PDF] Synthesis, Docking and Evaluation of Novel Pyr-azole Carboxamide Derivatives as Mul-tifunctional Anti-Alzheimer's Agents.(2017) J Med Chem Toxicol 2 (1): 1 …
V Lather - J Med Chem Toxicol, 2017 - researchgate.net
Alzheimer's disease (AD) is a major public health problem. The dual inhibitors of
monoamine oxidase-B (MAO-B) and acetyl cholinesterase (AchE) are reported as effective …
monoamine oxidase-B (MAO-B) and acetyl cholinesterase (AchE) are reported as effective …
Investigation of novel benzoxazole-oxadiazole derivatives as effective anti-Alzheimer's agents: in vitro and in silico approaches
Alzheimer's disease (AD) is a progressive neurological illness that is distinguished clinically
by cognitive and memory decline and adversely affects the people of old age. The …
by cognitive and memory decline and adversely affects the people of old age. The …
[HTML][HTML] Design, synthesis and in vitro biological activities of coumarin linked 1, 3, 4-oxadiazole hybrids as potential multi-target directed anti-Alzheimer agents
N George, B Al Sabahi, M AbuKhader… - Journal of King Saud …, 2022 - Elsevier
Introduction Alzheimer's disease (AD) is one of the most common and prevalent forms of
neurodegenerative diseases. Coumarin is a versatile scaffold that exhibits a wide range of …
neurodegenerative diseases. Coumarin is a versatile scaffold that exhibits a wide range of …
Synthesis, biological evaluation and molecular docking study of novel piperidine and piperazine derivatives as multi-targeted agents to treat Alzheimer's disease
P Meena, V Nemaysh, M Khatri, A Manral… - Bioorganic & medicinal …, 2015 - Elsevier
Abstract Development of Multi-Target Directed Ligands (MTDLs) has emerged as a
promising approach for targeting complex etiology of Alzheimer's disease (AD). Following …
promising approach for targeting complex etiology of Alzheimer's disease (AD). Following …
Naphthalene-triazolopyrimidine hybrid compounds as potential multifunctional anti-Alzheimer's agents
In an attempt to construct potential anti-Alzheimer's agents Naphthalene-triazolopyrimidine
hybrids were synthesized and screened in vitro against the two cholinesterases (ChE) s …
hybrids were synthesized and screened in vitro against the two cholinesterases (ChE) s …
Coumarin linked heterocyclic hybrids: a promising approach to develop multi target drugs for Alzheimer's disease
Alzheimer's disease (AD) is a major progressive and perplexing cortical degenerative
disease of the brain in the elderly. It contributes to a significant socioeconomic burden on …
disease of the brain in the elderly. It contributes to a significant socioeconomic burden on …
Pathogenesis of Alzheimer's Disease and Diversity of 1, 2, 3-Triazole Scaffold in Drug Development: Design Strategies, Structural Insights, and Therapeutic Potential
Alzheimer's disease is a most prevalent form of dementia all around the globe and currently
poses a significant challenge to the healthcare system. Currently available drugs only slow …
poses a significant challenge to the healthcare system. Currently available drugs only slow …
Recent developments in tacrine-based hybrids as a therapeutic option for Alzheimer's disease
C Yamali, S Donmez - Mini Reviews in Medicinal Chemistry, 2023 - ingentaconnect.com
Alzheimer's disease (AD) is a multifactorial, irreversible, and age-related neurodegenerative
disorder among the elderly. AD attracts attention due to its complex pathogenesis, morbidity …
disorder among the elderly. AD attracts attention due to its complex pathogenesis, morbidity …