Genome‐wide association aims to comprehensively survey genetic variation for the
purposes of disease and trait mapping. We provide a brief history of the development of …

Genetic association studies have made a major contribution to our understanding of the
genetics of complex disorders over the last 10 years through genome-wide association …

Hundreds of genome-wide association studies have been performed in recent years in order
to try to identify common variants that associate with complex disease. These have met with …

Genome‐wide association analysis appears to be a promising way to identify heritable
susceptibility factors for complex human disorders. However, the feasibility of large‐scale …

When the time came to decide on the topic for the next in the series of Human Molecular
Genetics reviews, on this occasion, there was little need for debate. The advent of genome …

Genome-wide association studies (GWAS) have led to a rapid increase in available data on
common genetic variants and phenotypes and numerous discoveries of new loci associated …

Objective: The authors conducted a review of the history and empirical basis of genomewide
association studies (GWAS), the rationale for GWAS of psychiatric disorders, results to date …

It is now commonly accepted that genes contribute to the etiology of many psychiatric
disorders. Estimates of the heritability for schizophrenia have been as high as 81%, 1 for …

Genome-wide association studies are utilized for gene discovery in common diseases.
Genotypes of large groups of unrelated patients are compared to controls. This has become …

In contrast with rare Mendelian (single-gene) diseases, the success rate of identification of
genes for complex traits and diseases through positional cloning (ie, fine-mapping of linkage …