Innate immune cells present a dual role during leishmaniasis: they constitute the first line of
host defense but are also the main host cells for the parasite. Response against the infection …

In the innate immunity to Leishmania infection tissue-resident macrophages and
inflammatory monocytes accumulate host-cell, effector, and efferocytosis functions. In …

In order to investigate the importance of the host microbiota on differentiation of T cell
subsets in response to infection, Swiss/NIH germ-free mice and conventional (microbiota …

Leishmania are protozoan parasites that predominantly reside in myeloid cells within their
mammalian hosts. Monocytes and macrophages play a central role in the pathogenesis of …

Leishmaniasis is a group of heterogenous diseases considered as an important public
health problem in several countries. This neglected disease is caused by over 20 parasite …

Leishmaniases are a group of diseases with different clinical manifestations. Macrophage-
Leishmania interactions are central to the course of the infection. The outcome of the …

Intracellular phagosomal pathogens represent a formidable challenge for innate immune
cells, as, paradoxically, these phagocytic cells can act as both host cells that support …

Innate lymphoid cells (ILCs) comprise a heterogeneous population of immune cells that
maintain barrier function and can initiate a protective or pathological immune response upon …

Macrophages are the major host cells for Leishmania parasites, and determine the fate of
infection by either limiting or allowing growth of the parasites, resulting in development or …

Infection by Leishmania takes place in the context of inflammation and tissue repair. Besides
tissue resident macrophages, inflammatory macrophages and neutrophils are recruited to …