The aim of this work was to compare hepatocellular toxicity and pharmacological activity of
amiodarone (2-n-butyl-3-[3, 5 diiodo-4-diethylaminoethoxybenzoyl]-benzofuran; B2-O-Et-N …

Amiodarone is a widely used potent antiarrhythmic for the treatment of cardiac disease;
however, its use is often discontinued due to numerous adverse effects, including …

Background and purpose: Amiodarone (2‐n‐butyl‐3‐[3, 5 diiodo‐4‐
diethylaminoethoxybenzoyl]‐benzofuran, B2‐O‐CH2CH2‐N‐diethyl) is an effective class III …

Background: Amiodarone is a well-known mitochondrial toxin consisting of a benzofuran
ring (ring A) coupled to a p-OH-benzene structure substituted with 2 iodines and a diethyl …

The possible roles of free radicals and lipid peroxidation in the mechanism of toxicity of
amiodarone (AD)[2-butyl-3-(3', 5'-diiodo-4'α-diethylaminoethoxybenzoyl) benzofuran] and its …

The prevalence of apparent amiodarone-related hepatic injury in 104 patients followed
prospectively is compared to that reported in the literature. Asymptomatic elevation of serum …

Amiodarone chlorhydrate is a diiodated benzofuran derivative used to treat cardiac rhythm
abnormalities. Hepatotoxicity is a relatively uncommon side effect of amiodarone and …

Amiodarone is a class III antiarrhythmic drug widely used for the treatment of both
supraventricular and ventricular arrhythmias in intensive care unit. Hepatotoxicity of …

Amiodarone is a class III antiarrhythmic drug with potentially life-threatening hepatotoxicity.
Recent in vitro investigations suggested that the mono-N-desethyl (MDEA) and di-N …

Potential hepatotoxicity related to amiodarone therapy is often a concern when deciding
whether to initiate or continue treatment with this medication. While mostly associated with …