Isocostunolide inhibited glioma stem cell by suppression proliferation and inducing caspase dependent apoptosis

Z Dai, SR Li, PF Zhu, L Liu, B Wang, YP Liu… - Bioorganic & Medicinal …, 2017 - Elsevier
Glioblastoma multiform (GBM) is a highly aggressive brain tumor with poor life expectancy,
and glioma stem cells (GSCs) are a small population of tumor cells existed in GBM, in which …

Erianin, a promising agent in the treatment of glioblastoma multiforme triggers apoptosis in U373 and A172 glioblastoma cells

KS Serter, M Seçme, L Elmas - Archives of Biological Sciences, 2022 - doiserbia.nb.rs
Glioblastoma is an aggressive, common and deadly primary intracranial brain tumor in
adults. The antitumor activity of erianin, a dibenzyl compound found in Dendrobium …

Apoptosis and necroptosis-inducing effects of arctigenin on nasal septum carcinoma RPMI-2650 cells in 2D and 3D culture

YJ Lee, KS Park, BJ Baek, KA Lee, SH Lee - Molecular & Cellular …, 2020 - Springer
Backgrounds Arctigenin derived from the seeds of Arctium lappa Linnaeus is known as an
anticancer drug candidate by targeting various pathways involved in anticancer therapy …

Selective cytotoxic and anti-metastatic activity in DU-145 prostate cancer cells induced by Annona muricata L. bark extract and phytochemical, annonacin

K Foster, O Oyenihi, S Rademan, J Erhabor… - … medicine and therapies, 2020 - Springer
Background Annona muricata L. was identified as a popular medicinal plant in treatment
regimens among cancer patients in Jamaica by a previously conducted structured …

Gardenia jasminoides Enhances CDDP-Induced Apoptosis of Glioblastoma Cells via AKT/mTOR Pathway While Protecting Death of Astrocytes

HI Kim, SH Hong, JM Ku, MJ Kim, SW Ju, SW Chang… - Nutrients, 2020 - mdpi.com
Gliomas are the most observed primary brain tumor, of which glioblastoma multiform (GBM)
shows the highest incidence. Radiotherapy with temozolomide is the standard therapeutic …

Asterosaponins from the starfish Astropecten monacanthus suppress growth and induce apoptosis in HL-60, PC-3, and SNU-C5 human cancer cell lines

NP Thao, BTT Luyen, EJ Kim, HK Kang… - Biological and …, 2014 - jstage.jst.go.jp
Using various chromatographic experiments, six asterosaponins (1− 6) were isolated from
the MeOH extract of the Vietnamese starfish Astropecten monacanthus. The cytotoxic …

Anti-tumor activity of Annona squamosa seeds extract containing annonaceous acetogenin compounds

Y Chen, S Xu, J Chen, Y Wang, H Xu, N Fan… - Journal of …, 2012 - Elsevier
ETHNOPHARMACOLOGICAL RELEVANCE: Seeds of Annona squamosa L. have been
used in the south of China as a folk remedy to treat “malignant sores”(cancer). AIM OF THE …

Cytotoxic Indole Alkaloid 3α-Acetonyltabersonine Induces Glioblastoma Apoptosis via Inhibition of DNA Damage Repair

Y Li, Y Zhao, X Zhou, W Ni, Z Dai, D Yang, J Hao, L Luo… - Toxins, 2017 - mdpi.com
Cytotoxic indole alkaloids from Melodinus suaveolens, which belongs to the toxic plant
family Apocynaceae, demonstrated impressive antitumor activities in many tumor types, but …

Galangin (GLN) promotes temozolomide-induced apoptosis in glioma cells

Y Li, Y Wan, N Yu, Y Zhao, M Li - Biology Bulletin, 2022 - Springer
The efficacy of Temozolomide (TMZ)-based chemotherapy in human malignancy is limited
by the occurrence of innate and acquired drug resistance. Hence, in the present study, we …

Medicarpin suppresses proliferation and triggeres apoptosis by upregulation of BID, BAX, CASP3, CASP8, and CYCS in glioblastoma

L Ying, M Hao, Z Zhang, R Guo, Y Liang… - Chemical Biology & …, 2023 - Wiley Online Library
Glioblastoma (GBM) is the most malignant brain tumor and incurable. Medicarpin (MED), a
flavonoid compound from the legume family, has multiple targets and anticancer properties …