Mice generated from tetraploid complementation competent iPS cells show similar developmental features as those from ES cells but are prone to tumorigenesis
Ever since the creation of induced pluripotent cells (iPSCs) from adult somatic cells by the
ectopic expression of defined transcription factors [1, 2], whether iPS cells are equivalent to …
ectopic expression of defined transcription factors [1, 2], whether iPS cells are equivalent to …
Viable mice produced from three-factor induced pluripotent stem (iPS) cells through tetraploid complementation
Ectopic expression of four transcription factors, including Oct4, Sox2, Klf4 and c-Myc, in
differentiated fibroblast cells could reset the cell fate of fibroblast cells to pluripotent state [1] …
differentiated fibroblast cells could reset the cell fate of fibroblast cells to pluripotent state [1] …
Production of mice using iPS cells and tetraploid complementation
Induced pluripotent stem cells (iPSCs) are considered to be an attractive alternative to
embryonic stem cells (ESCs) and may provide great potential for clinical applications in …
embryonic stem cells (ESCs) and may provide great potential for clinical applications in …
Pluripotency of induced pluripotent stem cells
L Kang, S Gao - Journal of animal science and biotechnology, 2012 - Springer
Recent studies have demonstrated that differentiated somatic cells from various mammalian
species can be reprogrammed into induced pluripotent stem (iPS) cells by the ectopic …
species can be reprogrammed into induced pluripotent stem (iPS) cells by the ectopic …
[PDF][PDF] iPS cells can support full-term development of tetraploid blastocyst-complemented embryos
L Kang, J Wang, Y Zhang, Z Kou, S Gao - Cell stem cell, 2009 - cell.com
To our knowledge, for the first time, we demonstrate that induced pluripotent stem cells
(iPSCs) can autonomously generate full-term mice via tetraploid blastocysts …
(iPSCs) can autonomously generate full-term mice via tetraploid blastocysts …
iPS cells generated without c-Myc have active Dlk1-Dio3 region and are capable of producing full-term mice through tetraploid complementation
Due to its ethical acceptability and technical feasibility, production of induced pluripotent
stem (iPS) cells from differentiated somatic cells by exogenous expression of several key …
stem (iPS) cells from differentiated somatic cells by exogenous expression of several key …
[HTML][HTML] New advances in iPS cell research do not obviate the need for human embryonic stem cells
I Hyun, K Hochedlinger, R Jaenisch, S Yamanaka - Cell Stem Cell, 2007 - cell.com
Recently three different studies were published demonstrating that mouse fibroblast (skin)
cells can be directly reprogrammed to behave like embryonic stem cells (Okita et al., 2007; …
cells can be directly reprogrammed to behave like embryonic stem cells (Okita et al., 2007; …
Viable fertile mice generated from fully pluripotent iPS cells derived from adult somatic cells
Previous studies demonstrated that induced pluripotent stem (iPS) cells could produce
viable mice through tetraploid complementation, which was thought to be the most stringent …
viable mice through tetraploid complementation, which was thought to be the most stringent …
Proliferation rate of somatic cells affects reprogramming efficiency
Y Xu, X Wei, M Wang, R Zhang, Y Fu, M Xing… - Journal of Biological …, 2013 - ASBMB
The discovery of induced pluripotent stem (iPS) cells provides not only new approaches for
cell replacement therapy, but also new ways for drug screening. However, the undefined …
cell replacement therapy, but also new ways for drug screening. However, the undefined …
Derivation of transgene-free rat induced pluripotent stem cells approximating the quality of embryonic stem cells
Although a variety of reprogramming strategies have been reported to create transgene-free
induced pluripotent stem (iPS) cells from differentiated cell sources, a fundamental question …
induced pluripotent stem (iPS) cells from differentiated cell sources, a fundamental question …