The ability of induced pluripotent stem cells (iPSCs) to differentiate into all adult cell types
makes them attractive for research and regenerative medicine; however, it remains unknown …

Murine pluripotent stem cells can exist in two functionally distinct states, LIF-dependent
embryonic stem cells (ESCs) and bFGF-dependent epiblast stem cells (EpiSCs). However …

Direct reprogramming of human somatic cells into pluripotency has broad implications in
generating patient-specific induced pluripotent stem (iPS) cells for disease modeling and …

Direct reprogramming of somatic cells provides an opportunity to generate patient-or
disease-specific pluripotent stem cells. Such induced pluripotent stem (iPS) cells were …

Pluripotent stem cells (PSCs) have the potential to differentiate into many cell types and
therefore can be a valuable source for cell therapy. Embryonic stem cells (ESCs), which are …

Although viable mice can be generated from induced pluripotent stem cells (iPSCs), the
impact of accumulated mutations on the developmental potential of the resulting iPSCs …

Background Somatic cells can be reprogrammed into induced pluripotent stem (iPS) cells.
Recently, selection of fully reprogrammed cells was achieved based on colony morphology …

In 1998, human embryonic stem cells were first generated and were expected to contribute
greatly to regenerative medicine. However, when medical treatments were performed using …

This unit describes a protocol for deriving induced pluripotent stem (iPS) cells from human
fibroblast cells. Human fibroblast cells are infected with retroviral vectors expressing four …

Human embryonic stem cells (ESCs) can be induced to differentiate into a wide range of
tissues that soon could be used for therapeutic applications in regenerative medicine …