Our current understanding of cystic fibrosis (CF) has revealed that the biophysical properties
of mucus play a considerable role in the pathogenesis of the disease in view of the fact that …

Mucus pathology in cystic fibrosis (CF) has been known for as long as the disease has been
recognized and is sometimes called mucoviscidosis. The disease is marked by mucus …

Cystic fibrosis (CF) is both the most common and most lethal genetic disease in the
Caucasian population. CF is caused by mutations in the cystic fibrosis transmembrane …

Cystic fibrosis (CF) is caused by a nonfunctional chloride and bicarbonate ion channel (CF
transmembrane regulator [CFTR]), but the link to the phenomenon of stagnant mucus is not …

Mucus plugging is a hallmark of cystic fibrosis, but the link between the defective gene
product, the cystic fibrosis transmembrane conductance regulator, and the abnormal mucus …

In the cystic fibrosis (CF) patient, lung function decreases throughout life as a result of
continuous cycles of infection, particularly with Pseudomonas aeruginosa and …

The pathogenesis of mucoinfective lung disease in cystic fibrosis (CF) patients likely
involves poor mucus clearance. A recent model of mucus clearance predicts that mucus flow …

The dynamics describing the vicious cycle characteristic of cystic fibrosis (CF) lung disease,
initiated by stagnant mucus and perpetuated by infection and inflammation, remain unclear …

Rationale: Cystic fibrosis (CF) airways disease produces a mucoobstructive lung phenotype
characterized by airways mucus plugging, epithelial mucous cell metaplasia/hyperplasia …

The clinical manifestations of cystic fibrosis (CF) result from dysfunction of the cystic fibrosis
transmembrane regulator protein (CFTR). The majority of people with CF have a limited life …