The kidney is a highly metabolic organ that requires substantial adenosine triphosphate for
the active transport required to maintain water and solute reabsorption. Aberrations in …

Abstract The kidneys compose approximately 0.5% of the body mass but consume about
10% of the oxygen in cellular respiration. This discordance is due to the high energy …

Acute kidney injury (AKI) continues to be a significant contributor to morbidity, mortality, and
health care expenditure. In the United States alone, it is estimated that more than $10 billion …

Acute kidney injury (AKI) significantly contributes to morbidity and mortality in critically ill
patients. AKI is also an independent risk factor for the development and progression of …

Per milligram of tissue, only the heart exceeds the kidney's abundance of mitochondria. Not
surprisingly, renal mitochondria are most densely concentrated in the epithelium of the …

Acute kidney injury (AKI) is a common clinical entity that is associated with high mortality and
morbidity. It is a risk factor for the development and progression of chronic kidney disease …

Recent studies show that it is now eminently feasible to pharmacologically manipulate
various key aspects of mitochondrial biology in the kidney, and this has much potential for …

There are unique features of renal oxygenation that render the kidney susceptible to oxygen
demand-supply mismatch and hypoxia. Renal oxygen consumption by oxidative metabolism …

Mitochondria are energy-producing organelles that not only satisfy the high metabolic
demands of the kidney but sense and respond to kidney injury-induced oxidative stress and …

Acute kidney injury (AKI) is a serious clinical condition with no effective treatment. Tubular
cells are key targets in AKI. Tubular cells and, specifically, proximal tubular cells are …