Drug design strategies that aim to improve the low solubility and poor bioavailability conundrum in quercetin derivatives

SR Alizadeh, N Savadkouhi… - Expert Opinion on Drug …, 2023 - Taylor & Francis
Introduction Scientists are especially interested in polyphenols, particularly flavonoids.
Quercetin, a flavonoid, has demonstrated various therapeutic properties, such as …

The biological activities, chemical stability, metabolism and delivery systems of quercetin: A review

W Wang, C Sun, L Mao, P Ma, F Liu, J Yang… - Trends in food science & …, 2016 - Elsevier
Background Quercetin, one of the most well-known flavonoids, has been included in human
diet for a long history. The use of quercetin has been widely associated with a great number …

Bioavailability of quercetin: problems and promises

X Cai, Z Fang, J Dou, A Yu… - Current medicinal …, 2013 - ingentaconnect.com
Quercetin (QC) is a typical plant flavonoid, possesses diverse pharmacologic effects
including antiinflammatory, antioxidant, anti-cancer, anti-anaphylaxis effects and against …

Enhancing the potential preclinical and clinical benefits of quercetin through novel drug delivery systems

R Khursheed, SK Singh, S Wadhwa, M Gulati… - Drug discovery today, 2020 - Elsevier
Highlights•Pharmacological activities and molecular targets of quercetin.•Mechanistic
pathways of quercetin for treating different diseases.•Formulation strategies for improving …

Quercetin derivatives: Drug design, development, and biological activities, a review

SR Alizadeh, MA Ebrahimzadeh - European journal of medicinal chemistry, 2022 - Elsevier
More studies are needed to develop new drugs for problems associated with drug
resistance and unfavorable side effects. The natural flavonoid of quercetin revealed a wide …

Quercetin in anti-diabetic research and strategies for improved quercetin bioavailability using polymer-based carriers–a review

P Mukhopadhyay, AK Prajapati - RSC advances, 2015 - pubs.rsc.org
With numerous pharmacological and biological functions bio-flavonoids gain appreciable
attention in diabetes and other therapeutic research. Among several beneficial flavonoids …

Quercetin: a potential polydynamic drug

N Georgiou, MG Kakava, EA Routsi, E Petsas… - Molecules, 2023 - mdpi.com
The study of natural products as potential drug leads has gained tremendous research
interest. Quercetin is one of those natural products. It belongs to the family of flavonoids and …

Promising bioactive properties of quercetin for potential food applications and health benefits: A review

I Shabir, V Kumar Pandey, R Shams, AH Dar… - Frontiers in …, 2022 - frontiersin.org
Naturally occurring phytochemicals with promising biological properties are quercetin and
its derivatives. Quercetin has been thoroughly studied for its antidiabetic, antibacterial, anti …

Quercetin as a therapeutic product: evaluation of its pharmacological action and clinical applications—a review

MA Mirza, S Mahmood, AR Hilles, A Ali, MZ Khan… - Pharmaceuticals, 2023 - mdpi.com
Quercetin is the major polyphenolic flavonoid that belongs to the class called flavanols. It is
found in many foods, such as green tea, cranberry, apple, onions, asparagus, radish leaves …

Recent advances in potential health benefits of quercetin

F Aghababaei, M Hadidi - Pharmaceuticals, 2023 - mdpi.com
Quercetin, a flavonoid found in fruits and vegetables, has been a part of human diets for
centuries. Its numerous health benefits, including antioxidant, antimicrobial, anti …