Evaluation of the inhibitory effect of Gynostemma pentaphyllum extracts on CYP450 enzyme activities using LC-MS/MS

JS Yu, YS Ji, SY Jo, XL Piao… - Mass Spectrometry …, 2023 - repository.hanyang.ac.kr
Gynostemma pentaphyllum (Thunb.) Makino extract, a natural product with a history of
traditional use, has gained attention for its potential health benefits. This study aimed to …

[HTML][HTML] Human cytochrome P450 enzyme modulation by Gymnema sylvestre: a predictive safety evaluation by LC-MS/MS

B Rammohan, K Samit, D Chinmoy, S Arup… - Pharmacognosy …, 2016 - ncbi.nlm.nih.gov
Background: Traditionally GS is used to treat diabetes mellitus. Drug-herb interaction of GS
via cytochrome P450 enzyme system by substrate cocktail method using HLM has not been …

Bioactive components of Glycyrrhiza uralensis mediate drug functions and properties through regulation of CYP450 enzymes

H Chen, X Zhang, Y Feng, W Rui… - Molecular Medicine …, 2014 - spandidos-publications.com
Glycyrrhiza uralensis (G. uralensis) is a common medicinal plant that has mainly been used
to modulate the pharmaceutical activity of herbal medicines. Although G. uralensis has been …

Metabolic profiling of Gynostemma pentaphyllum extract in rat serum, urine and faeces after oral administration

DJ Chen, HG Hu, SF Xing, YJ Gao, SF Xu… - … of Chromatography B, 2014 - Elsevier
Abstract Folk drug Gynostemma pentaphyllum (Thunb.) Makino contains many biologically
active phytochemicals which have been demonstrated to be effective against chronic …

In vitro Inhibitory Effect of Gymnema sylvestre Extracts and Total Gymnemic Acids Fraction on Select Cytochrome P450 Activities in Rat Liver Microsomes

M Vaghela, K Iyer, N Pandita - European Journal of Drug Metabolism and …, 2018 - Springer
Abstract Background and Objectives Gymnema sylvestre R. Br. is a well-known Indian
medicinal herb. Gymnemic acids are pentacyclic triterpenes saponins and active …

Inhibitory effects of gypenosides on seven human cytochrome P450 enzymes in vitro

M He, J Jiang, F Qiu, S Liu, P Peng, C Gao… - Food and chemical …, 2013 - Elsevier
Among the various possible causes for drug interactions, pharmacokinetic factors such as
inhibition of drug-metabolizing enzymes, especially cytochrome P450 (CYP) enzymes, are …

In vivo pharmacokinetic interaction by ethanolic extract of Gymnema sylvestre with CYP2C9 (Tolbutamide), CYP3A4 (Amlodipine) and CYP1A2 (Phenacetin) in rats

M Vaghela, N Sahu, P Kharkar, N Pandita - Chemico-Biological Interactions, 2017 - Elsevier
Gymnema sylvestre (GS) is a medicinal herb used for diabetes mellitus (DM). Herbs are
gaining popularity as medicines in DM for its safety purpose. The aim of the present study …

Characterization and Identification of the Chemical Constituents of Gynostemma pentaphyllum Using High Performance Liquid Chromatography – Electrospray …

Y Ling, Z Lei, X Li, X Yan, S Wang, W Yang… - Analytical …, 2020 - Taylor & Francis
Gynostemma pentaphyllum has gained increasing interest in recent years for its widespread
use as a medicinal plant, dietary supplement, herbal tea, and vegetable in China. This herb …

Exploring the Possible Metabolism Mediated Interaction of Glycyrrhiza glabra Extract with CYP3A4 and CYP2D6

S Pandit, S Ponnusankar… - Phytotherapy …, 2011 - Wiley Online Library
The rhizome of Glycyrrhiza glabra L.(licorice) is used very widely in Indian and Chinese
traditional medicine, and it is a popular flavor ingredient of drinks, sweets and candies. Its …

Chemical constituents and biological activity of Gynostemma pentaphyllum: a review.

ZX Wang, JM Yang, ZB Zhang, XT Zhu, P Xiang, J Sun… - 2023 - cabidigitallibrary.org
Gynostemma pentaphyllum (GP) is a significant edible plant resource in China. It is a grassy
climbing plant belonging to Gynostemma genus of Cucurbitaceae family and is extensively …