Human primary adipocytes exhibit immune cell function: adipocytes prime inflammation independent of macrophages
Background Obesity promotes inflammation in adipose tissue (AT) and this is implicated in
pathophysiological complications such as insulin resistance, type 2 diabetes and …
pathophysiological complications such as insulin resistance, type 2 diabetes and …
Adipose tissue macrophages: going off track during obesity
L Boutens, R Stienstra - Diabetologia, 2016 - Springer
Inflammation originating from the adipose tissue is considered to be one of the main driving
forces for the development of insulin resistance and type 2 diabetes in obese individuals …
forces for the development of insulin resistance and type 2 diabetes in obese individuals …
Chronic adipose tissue inflammation linking obesity to insulin resistance and type 2 diabetes
Obesity is one of the major health burdens of the 21st century as it contributes to the growing
prevalence of its related comorbidities, including insulin resistance and type 2 diabetes …
prevalence of its related comorbidities, including insulin resistance and type 2 diabetes …
[HTML][HTML] Crosstalk between adipocytes and immune cells in adipose tissue inflammation and metabolic dysregulation in obesity
Recent findings, notably on adipokines and adipose tissue inflammation, have revised the
concept of adipose tissues being a mere storage depot for body energy. Instead, adipose …
concept of adipose tissues being a mere storage depot for body energy. Instead, adipose …
[HTML][HTML] Adipose tissue inflammation in obesity and metabolic syndrome
S Nishimura, I Manabe, R Nagai - Discovery medicine, 2009 - discoverymedicine.com
Metabolic syndrome is a major risk factor for cardiovascular and metabolic diseases. Playing
a central role in the development of metabolic syndrome and in its clinical consequences is …
a central role in the development of metabolic syndrome and in its clinical consequences is …
The role of adipose tissue immune cells in obesity and low-grade inflammation
M Mraz, M Haluzik - Journal of Endocrinology, 2014 - joe.bioscientifica.com
Adipose tissue (AT) lies at the crossroad of nutrition, metabolism, and immunity; AT
inflammation was proposed as a central mechanism connecting obesity with its metabolic …
inflammation was proposed as a central mechanism connecting obesity with its metabolic …
Adipose tissue macrophages and their polarization in health and obesity
L Catrysse, G van Loo - Cellular immunology, 2018 - Elsevier
Adipose tissue is a special tissue environment due to its high lipid content. Adipose tissue
macrophages (ATMs) help maintain adipose tissue homeostasis in steady state by clearing …
macrophages (ATMs) help maintain adipose tissue homeostasis in steady state by clearing …
Adipose tissue macrophages
M Zeyda, TM Stulnig - Immunology letters, 2007 - Elsevier
It is now broadly accepted that low-grade chronic inflammation associated with obesity leads
to the onset of insulin resistance and type 2 diabetes mellitus. Obesity-associated …
to the onset of insulin resistance and type 2 diabetes mellitus. Obesity-associated …
Adipose tissue inflammation in the pathogenesis of type 2 diabetes
A Kohlgruber, L Lynch - Current diabetes reports, 2015 - Springer
At least 2.8 million people die each year as a result of being overweight or obese, and the
biggest burden being obesity-related diseases. Overweight and obesity account for a major …
biggest burden being obesity-related diseases. Overweight and obesity account for a major …
The “Big Bang” in obese fat: Events initiating obesity‐induced adipose tissue inflammation
Obesity is associated with the accumulation of pro‐inflammatory cells in visceral adipose
tissue (VAT), which is an important underlying cause of insulin resistance and progression to …
tissue (VAT), which is an important underlying cause of insulin resistance and progression to …