The Metabolism of Salidroside to Its Aglycone p-Tyrosol in Rats following the Administration of Salidroside

N Guo, M Zhu, X Han, D Sui, Y Wang, Q Yang - PLoS One, 2014 - journals.plos.org
Salidroside is one of the major phenolic glycosides in Rhodiola, which has been reported to
possess various biological activities. In the present study the in vivo deglycosylation …

Simultaneous Determination of Salidroside and Its Aglycone Metabolite p-Tyrosol in Rat Plasma by Liquid Chromatography-Tandem Mass Spectrometry

N Guo, Z Hu, X Fan, J Zheng, D Zhang, T Xu, T Yu… - Molecules, 2012 - mdpi.com
Salidroside and its aglycone p-tyrosol are two major phenols in the genus Rhodiola and
have been confirmed to possess various pharmacological properties. In our present study, p …

Metabolic profile of salidroside in rats using high-performance liquid chromatography combined with Fourier transform ion cyclotron resonance mass spectrometry

F Han, Y Li, X Mao, X Zhang, J Guan, A Song… - Analytical and …, 2016 - Springer
A high-performance liquid chromatography coupled to Fourier transform ion cyclotron
resonance mass spectrometry (HPLC-FT-ICR MS) method was developed to study the in …

Pharmacokinetics, tissue distribution, and excretion of salidroside in rats

Y Zhang, L Li, L Lin, J Liu, Z Zhang, D Xu… - Planta …, 2013 - thieme-connect.com
The present study investigated the pharmacokinetics, excretion, and tissue distribution of
salidroside, a main active constituent in the roots of Rhodiola species. The plasma …

An LC–MS/MS method for the determination of salidroside and its metabolite p-tyrosol in rat liver tissues

N Guo, W Ding, Y Wang, Z Hu, Z Wang… - Pharmaceutical …, 2014 - Taylor & Francis
Context: Salidroside and its metabolite p-tyrosol are two major phenols in the genus
Rhodiola L.(Crassulaceae). They have been confirmed to possess various pharmacological …

Metabolite profile of salidroside in rats by ultraperformance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry and high-performance …

Z Hu, Z Wang, Y Liu, Y Wu, X Han… - Journal of agricultural …, 2015 - ACS Publications
In the present work, the salidroside metabolite profile in rat urine was investigated, and
subsequently the metabolic pathways of salidroside were proposed. After administrations of …

Development and validation of a liquid chromatographic/electrospray ionization mass spectrometric method for the determination of salidroside in rat plasma …

S Yu, L Liu, T Wen, Y Liu, D Wang, Y He… - … of Chromatography B, 2008 - Elsevier
A sensitive and specific liquid chromatography–electrospray ionization-mass spectrometry
(LC–ESI-MS) method has been developed and validated for the identification and …

[PDF][PDF] Enhancing the biosynthesis of salidroside by biotransformation of p-tyrosol in callus culture of Rhodiola rosea L

A Krajewska-Patan, M Furmanowa, M Dreger… - Herba Pol, 2007 - academia.edu
The aim of this research was to enhance the content of salidroside by exogenous addition of
p-tyrosol in R. rosea tissue cultures. The callus tissue cultured on solid medium (MS with …

Quantitative determination of salidroside in rat plasma by on-line solid-phase extraction integrated with high-performance liquid chromatography/electrospray …

YW Chang, HT Yao, SH Hsieh, TJ Lu, TK Yeh - Journal of Chromatography …, 2007 - Elsevier
A method for the quantification of salidroside, a major biologically active compound in
Rhodiola, in rat plasma by on-line SPE LC/MS/MS in negative electrospray mode was …

Salidroside-can it be a multifunctional drug?

SKJ Magani, SD Mupparthi, BP Gollapalli… - Current Drug …, 2020 - ingentaconnect.com
Background: Salidroside is a glucoside of tyrosol found mostly in the roots of Rhodiola spp. It
exhibits diverse biological and pharmacological properties. In the last decade, enormous …