Estrogen regulates myogenic tone in hippocampal arterioles by enhanced basal release of nitric oxide and endothelial SKCa channel activity

DA Jeffrey, A Russell, MB Guerrero, JT Fontaine… - bioRxiv, 2023 - biorxiv.org
Arteries and arterioles exhibit myogenic tone, a partially constricted state that allows further
constriction or dilation in response to moment-to-moment fluctuations in blood pressure. The …

Estrogen reduces myogenic tone through a nitric oxide-dependent mechanism in rat cerebral arteries

GG Geary, DN Krause… - American Journal of …, 1998 - journals.physiology.org
Gender differences in the incidence of stroke and migraine appear to be related to
circulating levels of estrogen; however, the underlying mechanisms are not yet understood …

[HTML][HTML] Considering Sex as a Biological Variable in Cardiovascular Research: Cerebral arteriolar and neurovascular dysfunction after chemically induced …

JA Blackwell, JF Silva, EM Louis, A Savu… - American Journal of …, 2022 - ncbi.nlm.nih.gov
Cognitive decline is linked to decreased cerebral blood flow, particularly in women after
menopause. Impaired cerebrovascular function precedes the onset of dementia, possibly …

Cerebral arteriolar and neurovascular dysfunction after chemically induced menopause in mice

JA Blackwell, JF Silva, EM Louis… - American Journal …, 2022 - journals.physiology.org
Cognitive decline is linked to decreased cerebral blood flow, particularly in women after
menopause. Impaired cerebrovascular function precedes the onset of dementia, possibly …

Aging influences cerebrovascular myogenic reactivity and BK channel function in a sex-specific manner

JT Reed, T Pareek, S Sriramula… - Cardiovascular …, 2020 - academic.oup.com
Aims The myogenic reactivity of the middle cerebral arteries (MCA) protects the brain by
altering the diameter in response to changes in lumen pressure. Large conductance …

Estrogen regulates myogenic tone in pressurized cerebral arteries by enhanced basal release of nitric oxide

P Skarsgard, C Van Breemen… - American Journal of …, 1997 - journals.physiology.org
Second-order middle cerebral arteries (135.0±4.6 μm ID) from male, female, ovariectomized
female (no endogenous estrogen), and estrogen-treated ovariectomized female Sprague …

Nitric-oxide-dependent pial arteriolar dilation in the female rat: effects of chronic estrogen depletion and repletion

DA Pelligrino, S Ye, F Tan, RA Santizo… - Biochemical and …, 2000 - Elsevier
In this study, we compared endothelial nitric oxide synthase (eNOS)-mediated cerebral
vasodilating responses in intact female rats, chronically ovariectomized (OVX) rats, and OVX …

Estrogen reduces mouse cerebral artery tone through endothelial NOS-and cyclooxygenase-dependent mechanisms

GG Geary, DN Krause… - American Journal of …, 2000 - journals.physiology.org
Gender and estrogen status are known to influence the incidence and severity of
cerebrovascular disease. The vasoprotective effects of estrogen are thought to include both …

Gonadal hormones affect diameter of male rat cerebral arteries through endothelium-dependent mechanisms

GG Geary, DN Krause… - American Journal of …, 2000 - journals.physiology.org
Gender is known to influence the incidence and severity of cerebrovascular disease. In the
present study, luminal diameter was measured in vitro in pressurized middle cerebral artery …

Influence of sex, hormones and age on cerebrovascular function: role of large conductance potassium channel subunits

MR Pabbidi, M Kuppusamy, T Pareek, BT Alexander… - …, 2017 - Am Heart Assoc
Although adult females are protected, the cerebrovascular disease is greater in aged post-
menopause females than in age matched males, but the role of vascular function and large …