Mitochondria play a primary role in cellular energetic metabolism, homeostasis, and death.
They possess their own multicopy genome, which is maternally transmitted. Mitochondria …

Mitochondria are well known as 'the powerhouses of the cell'. Indeed, their major role is
cellular energy production driven by both mitochondrial and nuclear DNA. Such a feature …

In mammals, mitochondria and mitochondrial DNA (mtDNA) are transmitted through the
female germ line. Mature oocytes contain at least 100,000 copies of mtDNA, organized at 1 …

It is likely that there is an association between the fitness of mitochondria and their ability to
support normal cellular function. Oocytes are greatly enriched in the number of mitochondria …

This review examines the place of mitochondria in the life cycle through oogenesis,
ovulation and early embryogenesis. Mitochondria are semi-autonomous organelles …

Mitochondria are the key regulators of multiple vital cellular processes, including apoptosis,
calcium homeostasis, and the generation of ATP via the metabolic pathway known as …

Mitochondria play a key role in a number of physiological events during all stages of life,
including the very first stages following fertilization. It is, therefore, important to understand …

Mitochondrial DNA (mtDNA) point mutations are known to accumulate in an age-dependent
fashion in somatic tissues. This study investigated whether a point mutation (T414G) in the …

Mitochondrial DNA content varies considerably in oocytes, even when collected from the
same patient. In the present study, real-time quantitative polymerase chain reaction analysis …

In addition to their role in generating energy (ATP), other possible regulatory functions for
mitochondria in the mature oocyte, preimplantation stage embryo and differentiating …