Comprehensive high-resolution mass spectrometric analysis of DNA phosphate adducts formed by the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3 …
The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK, 1) is
a potent lung carcinogen in laboratory animals and is believed to play a key role in the …
a potent lung carcinogen in laboratory animals and is believed to play a key role in the …
Identification of more than 100 structurally unique DNA-phosphate adducts formed during rat lung carcinogenesis by the tobacco-specific nitrosamine 4 …
Abstract The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
(NNK) is a powerful lung carcinogen in animal models and is considered a causative factor …
(NNK) is a powerful lung carcinogen in animal models and is considered a causative factor …
Mass Spectrometric Quantitation of Pyridyloxobutyl DNA Phosphate Adducts in Rats Chronically Treated with N′-Nitrosonornicotine
The tobacco-specific carcinogens N′-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-
1-(3-pyridyl)-1-butanone (NNK) require metabolic activation to exert their carcinogenicity …
1-(3-pyridyl)-1-butanone (NNK) require metabolic activation to exert their carcinogenicity …
Characterization and mapping of DNA damage induced by reactive metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) at nucleotide resolution in …
JF Cloutier, R Drouin, M Weinfeld, TR O'Connor… - Journal of Molecular …, 2001 - Elsevier
The nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is an important
tobacco-specific carcinogen associated with lung cancer. Its complex enzymatic activation …
tobacco-specific carcinogen associated with lung cancer. Its complex enzymatic activation …
The Pyridyloxobutyl DNA Adduct, O6-[4-Oxo-4-(3-pyridyl)butyl]guanine, Is Detected in Tissues from 4-(Methylnitrosamino)- 1-(3-pyridyl)-1-butanone-treated A/J Mice
NM Thomson, PM Kenney… - Chemical research in …, 2003 - ACS Publications
The tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), is
a potent pulmonary carcinogen. This unsymmetric nitrosamine can be metabolically …
a potent pulmonary carcinogen. This unsymmetric nitrosamine can be metabolically …
Mass spectrometric analysis of relative levels of pyridyloxobutylation adducts formed in the reaction of DNA with a chemically activated form of the tobacco-specific …
SJ Sturla, J Scott, Y Lao, SS Hecht… - Chemical research in …, 2005 - ACS Publications
Exposure to the tobacco-related nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-
butanone (NNK) and N '-nitrosonornicotine is carcinogenic to humans. Metabolic activation …
butanone (NNK) and N '-nitrosonornicotine is carcinogenic to humans. Metabolic activation …
Methyl DNA phosphate adduct formation in rats treated chronically with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite 4 …
The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a
powerful lung carcinogen in animal models and is considered a causative factor for lung …
powerful lung carcinogen in animal models and is considered a causative factor for lung …
Quantitation of pyridyloxobutyl DNA adducts of tobacco-specific nitrosamines in rat tissue DNA by high-performance liquid chromatography− electrospray ionization …
Y Lao, PW Villalta, SJ Sturla, M Wang… - Chemical research in …, 2006 - ACS Publications
The tobacco-specific nitrosamines N '-nitrosonornicotine (NNN, 1) and 4-
(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK, 2) are potent carcinogens in rodents …
(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK, 2) are potent carcinogens in rodents …
Liquid chromatography-tandem mass spectrometry for the quantification of tobacco-specific nitrosamine-induced DNA adducts in mammalian cells
Quantification of DNA lesions constitutes one of the main tasks in toxicology and in
assessing health risks accompanied by exposure to carcinogens. Tobacco-specific …
assessing health risks accompanied by exposure to carcinogens. Tobacco-specific …
Identification of 4-(3-pyridyl)-4-oxobutyl-2′-deoxycytidine adducts formed in the reaction of DNA with 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone: A …
AK Michel, AT Zarth, P Upadhyaya, SS Hecht - ACS omega, 2017 - ACS Publications
Metabolic activation of the carcinogenic tobacco-specific nitrosamines 4-(methylnitrosamino)-
1-(3-pyridyl)-1-butanone (NNK, 1) and N′-nitrosonornicotine (NNN, 2) results in the …
1-(3-pyridyl)-1-butanone (NNK, 1) and N′-nitrosonornicotine (NNN, 2) results in the …