Epithelial–mesenchymal transitions play key roles in development and cancer and entail the
loss of epithelial polarity and cell adhesion. In this study, we use quantitative live imaging of …

Cell delamination is a conserved morphogenetic process important for the generation of cell
diversity and maintenance of tissue homeostasis. Here, we used Drosophila embryonic …

Although Snail is essential for disassembly of adherens junctions during epithelial–
mesenchymal transitions (EMTs), loss of adherens junctions in Drosophila melanogaster …

During development, coordinated cell shape changes and cell divisions sculpt tissues.
While these individual cell behaviors have been extensively studied, how cell shape …

Proper control of epithelial morphogenesis is vital to development and is often disrupted in
disease. After germ band extension, the cells of the Drosophila ventral embryonic epidermis …

Invagination of the epithelial cell sheet of the prospective mesoderm in Drosophila
gastrulation is a well-studied, relatively simple morphogenetic event that results from …

Programmed patterns of gene expression, cell-cell signaling, and cellular forces cause
morphogenic movements during dorsal closure. We investigated the apical cell-shape …

Epithelial− mesenchymal transition (EMT) is an essential process both in physiological and
pathological contexts. Intriguingly, EMT is often associated with tissue invagination during …

During development, forces transmitted between cells are critical for sculpting epithelial
tissues. Actomyosin contractility in the middle of the cell apex (medioapical) can change cell …

During morphogenesis, extracellular signals trigger actomyosin contractility in
subpopulations of cells to coordinate changes in cell shape. To illuminate the link between …