One of the characteristic features of the majority of pancreatic ductal adenocarcinomas is an
abundant desmoplastic/stromal reaction. Until recently, this stroma had received little …

Pancreatic cancer is a devastating disease with an unacceptably high mortality to incidence
ratio. Traditional therapeutic approaches such as surgery in combination with chemo-or …

Pancreatic cancer is characterised by a prominent desmoplastic/stromal reaction that has
received little attention until recent times. Given that treatments focusing on pancreatic …

The abundant stromal/desmoplastic reaction, a characteristic feature of a majority of
pancreatic adenocarcinomas (PDAC), has only recently been receiving some attention …

Pancreatic cancer is characterized by its late detection, aggressive growth, intense
infiltration into adjacent tissue, early metastasis, resistance to chemo-and radiotherapy and …

Tumour-stromal interactions have now been acknowledged to play a major role in
pancreatic cancer (PC) progression. The abundant collagenous stroma is produced by a …

Pancreatic stellate cells (PSCs) were identified in the early 1980s, but received much
attention after 1998 when the methods to isolate and culture them from murine and human …

Pancreatic cancer—a tumor displaying a particularly abundant stromal reaction—is
notorious for its poor prognosis. Recent studies, via newly developed orthotopic models …

Pancreatic stellate cells (PSCs) are responsible for producing the collagenous stroma in
pancreatic cancer. Findings from the majority of in vitro and in vivo studies to date indicate …

Pancreatic ductal adenocarcinoma is an aggressive and highly lethal disease frequently
characterized by a dense stromal or desmoplastic response. Accumulating evidence exists …